干旱区生态环境知识资源中心(Arid): Prognostic utility of pre- and postoperative plasma L-lactate measurements in hospitalized cows with acute abdominal emergencies

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DOI	10.3168/jds.2020-19102
	Prognostic utility of pre- and postoperative plasma L-lactate measurements in hospitalized cows with acute abdominal emergencies
	Giertzuch, S.; Lorch, A.; Lausch, C. K.; Knubben-Schweizer, G.; Trefz, F. M.
通讯作者	Trefz, FM (corresponding author), Ludwig Maximilians Univ LMU Munich, Ctr Clin Vet Med, Clin Ruminants Ambulatory & Herd Hlth Serv, Sonnenstr 16, D-85764 Oberschleissheim, Germany. ; Trefz, FM (corresponding author), Univ Bern, Vetsuisse Fac, Clin Ruminants, Bremgartenstr 109a, CH-3012 Bern, Switzerland.
来源期刊	JOURNAL OF DAIRY SCIENCE
ISSN	0022-0302
EISSN	1525-3198
出版年	2020
卷号	103 期号:12 页码:11769-11781
英文摘要	The aim of the present analyses was to compare the prognostic value of pre- and postoperative L-lactate measurements in hospitalized cows requiring surgical intervention for an acute abdominal emergency, such as gastrointestinal ileus or peritonitis. For this purpose, we analyzed data from retro- and prospective case series, consisting of 754 and 98 cows, respectively. Plasma L-lactate concentrations (L-LAC) were determined upon admission to the hospital (both study populations), immediately before initiation of surgical intervention (prospective study population), and 6, 12, 24, 48, and 72 h later (prospective study population). The outcome of cows was evaluated until hospital discharge (both study populations) and 3 mo after discharge by a phone call to the farmer (prospective study population). A negative outcome was defined as death or euthanasia during hospitalization, or if discharged animals had an unsatisfied owner or were culled for medical reasons that were directly related to the initial abdominal emergency. For the retrospective study population, the overall survival rate until hospital discharge was 66%. Cows with a negative outcome (median: 6.81 mmol/L) had significantly higher L-LAC than cows with a positive outcome (3.66 mmol/L) of therapy. At the individual diagnosis level, L-LAC was associated with mortality in cows with a diagnosis of abomasal volvulus, local peritonitis, hemorrhagic bowel syndrome, and jejunal volvulus. Considering the whole study population, the area under the receiver operating characteristic curve was 0.66. For the prospective study population, the proportion of cows with a positive outcome was 65% until hospital discharge and 61% after the 3-mo observation period. At all sampling times, before arid during the first 12 h after surgical intervention, cows with a negative outcome had significantly higher L LAC than cows with a positive outcome. The largest area under the receiver operating characteristic curve for L-LAC was observed at 6 h (0.89). A cut-point of 1.77 mmol/L was identified, which had a sensitivity and specificity for predicting a negative outcome until hospital discharge of 88.9 and 73.4%, respectively. The present analyses confirmed previous findings in calves and show that persistent hyper-L-lactatemia during the early postoperative period is a more reliable indicator for a negative outcome than hyper-L-lactatemia before initiation of surgical intervention.
英文关键词	cow gastrointestinal ileus peritonitis hyper-L-lactatemia mortality
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000603029300021
WOS关键词	DAIRY-CATTLE ; BLOOD ; VOLVULUS ; PATHOPHYSIOLOGY ; DISPLACEMENT ; VALIDATION ; INDICATORS ; ABOMASUM ; HORSES ; DOGS
WOS类目	Agriculture, Dairy & Animal Science ; Food Science & Technology
WOS研究方向	Agriculture ; Food Science & Technology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/369160
作者单位	[Giertzuch, S.; Lorch, A.; Lausch, C. K.; Knubben-Schweizer, G.; Trefz, F. M.] Ludwig Maximilians Univ LMU Munich, Ctr Clin Vet Med, Clin Ruminants Ambulatory & Herd Hlth Serv, Sonnenstr 16, D-85764 Oberschleissheim, Germany; [Trefz, F. M.] Univ Bern, Vetsuisse Fac, Clin Ruminants, Bremgartenstr 109a, CH-3012 Bern, Switzerland
推荐引用方式 GB/T 7714	Giertzuch, S.,Lorch, A.,Lausch, C. K.,et al. Prognostic utility of pre- and postoperative plasma L-lactate measurements in hospitalized cows with acute abdominal emergencies[J],2020,103(12):11769-11781.
APA	Giertzuch, S.,Lorch, A.,Lausch, C. K.,Knubben-Schweizer, G.,&Trefz, F. M..(2020).Prognostic utility of pre- and postoperative plasma L-lactate measurements in hospitalized cows with acute abdominal emergencies.JOURNAL OF DAIRY SCIENCE,103(12),11769-11781.
MLA	Giertzuch, S.,et al."Prognostic utility of pre- and postoperative plasma L-lactate measurements in hospitalized cows with acute abdominal emergencies".JOURNAL OF DAIRY SCIENCE 103.12(2020):11769-11781.