干旱区生态环境知识资源中心(Arid): Ecotoxicological impact of the antihypertensive valsartan on earthworms, extracellular enzymes and soil bacterial communities

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DOI	10.1016/j.envpol.2021.116647
	Ecotoxicological impact of the antihypertensive valsartan on earthworms, extracellular enzymes and soil bacterial communities
	Gallego, Sara; Nos, David; Montemurro, Nicola; Sanchez-Hernandez, Juan C.; Perez, Sandra; Sole, Montserrat; Martin-Laurent, Fabrice
通讯作者	Martin-Laurent, F (corresponding author), INRAE, Agroecol, 17 Rue Sully,BP86510, F-21065 Dijon, France.
来源期刊	ENVIRONMENTAL POLLUTION
ISSN	0269-7491
EISSN	1873-6424
出版年	2021
卷号	275
英文摘要	The use of reclaimed water in agriculture represents a promising alternative to relieve pressure on freshwater supplies, especially in arid or semiarid regions facing water scarcity. However, this implies introducing micropollutants such as pharmaceutical residues into the environment. The fate and the ecotoxicological impact of valsartan, an antihypertensive drug frequently detected in wastewater effluents, were evaluated in soil-earthworm microcosms. Valsartan dissipation in the soil was concomitant with valsartan acid formation. Although both valsartan and valsartan acid accumulated in earthworms, no effect was observed on biomarkers of exposure (acetylcholinesterase, glutathione S-transferase and carboxylesterase activities). The geometric mean index of soil enzyme activity increased in the soils containing earthworms, regardless of the presence of valsartan. Therefore, earthworms increased soil carboxylesterase, dehydrogenase, alkaline phosphatase, beta-glucosidase, urease and protease activities. Although bacterial richness significantly decreased following valsartan exposure, this trend was enhanced in the presence of earthworms with a significant impact on both alpha and beta microbial diversity. The operational taxonomic units involved in these changes were related to four (Proteobacteria, Bacteroidetes, Actinobacteria and Firmicutes) of the eight most abundant phyla. Their relative abundances significantly increased in the valsartan-treated soils containing earthworms, suggesting the presence of potential valsartan degraders. The ecotoxicological effect of valsartan on microbes was strongly altered in the earthworm-added soils, hence the importance of considering synergistic effects of different soil organisms in the environmental risk assessment of pharmaceutical active compounds. (C) 2021 Elsevier Ltd. All rights reserved.
英文关键词	Pharmaceuticals Ecotoxicology Microbial ecotoxicology Soil
类型	Article
语种	英语
开放获取类型	Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000625380600051
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/368854
作者单位	[Gallego, Sara; Martin-Laurent, Fabrice] Univ Bourgogne Franche Comte, Univ Bourgogne, AgroSup Dijon, INRAE,Agroecol Dijon, Dijon, France; [Nos, David; Montemurro, Nicola; Perez, Sandra] IDAEA CSIC, ENFOCHEM, C Jordi Girona 18-26, Barcelona 08034, Spain; [Nos, David; Sole, Montserrat] Inst Marine Sci ICM CSIC, Renewable Marine Resources Dept, Barcelona, Spain; [Sanchez-Hernandez, Juan C.] Univ Castilla La Mancha, Inst Environm Sci ICAM, Lab Ecotoxicol, Toledo 45071, Spain
推荐引用方式 GB/T 7714	Gallego, Sara,Nos, David,Montemurro, Nicola,et al. Ecotoxicological impact of the antihypertensive valsartan on earthworms, extracellular enzymes and soil bacterial communities[J],2021,275.
APA	Gallego, Sara.,Nos, David.,Montemurro, Nicola.,Sanchez-Hernandez, Juan C..,Perez, Sandra.,...&Martin-Laurent, Fabrice.(2021).Ecotoxicological impact of the antihypertensive valsartan on earthworms, extracellular enzymes and soil bacterial communities.ENVIRONMENTAL POLLUTION,275.
MLA	Gallego, Sara,et al."Ecotoxicological impact of the antihypertensive valsartan on earthworms, extracellular enzymes and soil bacterial communities".ENVIRONMENTAL POLLUTION 275(2021).