干旱区生态环境知识资源中心(Arid): m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma

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DOI	10.1093/bib/bbab013
	m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma
	Du, Jianyang; Ji, Hang; Ma, Shuai; Jin, Jiaqi; Mi, Shan; Hou, Kuiyuan; Dong, Jiawei; Wang, Fang; Zhang, Chaochao; Li, Yuan; Hu, Shaoshan
通讯作者	Hu, SS (corresponding author), Harbin Med Univ, Dept Neurosurg, Affiliated Hosp 2, 157 Baojian Rd, Harbin 150086, Peoples R China. ; Li, Y (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Pharmacol, Jinan 250012, Shandong, Peoples R China.
来源期刊	BRIEFINGS IN BIOINFORMATICS
ISSN	1467-5463
EISSN	1477-4054
出版年	2021
卷号	22 期号:5
英文摘要	m6A RNA methylation is an emerging epigenetic modification, and its potential role in immunity and sternness remains unknown. Based on 17 widely recognized m6A regulators, the m6A modification patterns and corresponding characteristics of immune infiltration and sternness of 1152 low-grade glioma samples were comprehensively analyzed. Machine-learning strategies for constructing m6AScores were trained to quantify the m6A modification patterns of individual samples. Here, we reveal a significant correlation between the multi-omics data of regulators and clinicopathological parameters. We identified two distinct m6A modification patterns (an immune-activated differentiation pattern and an immune-desert dedifferentiation pattern) and four regulatory patterns of m6A methylation on immunity and sternness. We show that the m6AScores can predict the molecular subtype of low-grade glioma, the abundance of immune infiltration, the enrichment of signaling pathways, gene variation and prognosis. The concentration of high immunogenicity and clinical benefits in the low-m6AScore group confirmed the sensitive response to radio-chemotherapy and immunotherapy in patients with high-m6AScore. The results of the pan-cancer analyses illustrate the significant correlation between m6AScore and clinical outcome, the burden of neoepitope, immune infiltration and sternness. The assessment of individual tumor m6A modification patterns will guide us in improving treatment strategies and developing objective diagnostic tools. [GRAPHICS] .
英文关键词	m6A tumor immune microenvironment stemness machine learning immunotherapy pan-cancer
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000709461800055
WOS关键词	M(6)A MODIFICATION ; IMMUNOTHERAPY ; LEUKEMIA ; FEATURES ; RNAS
WOS类目	Biochemical Research Methods ; Mathematical & Computational Biology
WOS研究方向	Biochemistry & Molecular Biology ; Mathematical & Computational Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/368459
作者单位	[Du, Jianyang; Ji, Hang; Ma, Shuai; Jin, Jiaqi; Mi, Shan; Hou, Kuiyuan; Dong, Jiawei; Wang, Fang; Hu, Shaoshan] Harbin Med Univ, Dept Neurosurg, Affiliated Hosp 2, 157 Baojian Rd, Harbin 150086, Peoples R China; [Li, Yuan] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Dept Pharmacol, Jinan 250012, Shandong, Peoples R China; [Zhang, Chaochao] First Hosp Jilin Univ, Dept Neurosurg, Changchun, Peoples R China
推荐引用方式 GB/T 7714	Du, Jianyang,Ji, Hang,Ma, Shuai,et al. m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma[J],2021,22(5).
APA	Du, Jianyang.,Ji, Hang.,Ma, Shuai.,Jin, Jiaqi.,Mi, Shan.,...&Hu, Shaoshan.(2021).m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma.BRIEFINGS IN BIOINFORMATICS,22(5).
MLA	Du, Jianyang,et al."m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma".BRIEFINGS IN BIOINFORMATICS 22.5(2021).