干旱区生态环境知识资源中心(Arid): Spatially confined sub-tumor microenvironments in pancreatic cancer

Arid

DOI	10.1016/j.cell.2021.09.022
	Spatially confined sub-tumor microenvironments in pancreatic cancer
	Grunwald, Barbara T.; Devisme, Antoine; Andrieux, Geoffroy; Vyas, Foram; Aliar, Kazeera; McCloskey, Curtis W.; Macklin, Andrew; Jang, Gun Ho; Denroche, Robert; Romero, Joan Miguel; Bavi, Prashant; Bronsert, Peter; Notta, Faiyaz; O'Kane, Grainne; Wilson, Julie; Knox, Jennifer; Tamblyn, Laura; Udaskin, Molly; Radulovich, Nikolina; Fischer, Sandra E.; Boerries, Melanie; Gallinger, Steven; Kislinger, Thomas; Khokha, Rama
通讯作者	Kislinger, T ; Khokha, R (corresponding author), Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada. ; Boerries, M (corresponding author), Univ Freiburg, Med Ctr Univ Freiburg, Fac Med, Inst Med Bioinformat & Syst Med, D-79110 Freiburg, Germany. ; Boerries, M (corresponding author), German Canc Consortium DKTK, D-79110 Freiburg, Germany. ; Boerries, M (corresponding author), German Canc Res Ctr, Partner Site Freiburg, D-79110 Freiburg, Germany. ; Kislinger, T ; Khokha, R (corresponding author), Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada. ; Gallinger, S (corresponding author), Ontario Inst Canc Res, PanCuRx Translat Res Initiat, Toronto, ON M5G 0A3, Canada. ; Gallinger, S (corresponding author), Univ Toronto, Dept Surg, Toronto, ON M5T 1P5, Canada. ; Gallinger, S (corresponding author), Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada. ; Gallinger, S (corresponding author), Univ Hlth Network, Hepatobiliary Pancreat Surg Oncol Program, Toronto, ON M5G 2M9, Canada.
来源期刊	CELL
ISSN	0092-8674
EISSN	1097-4172
出版年	2021
卷号	184 期号:22 页码:5577-+
英文摘要	Intratumoral heterogeneity is a critical frontier in understanding how the tumor microenvironment (TME) propels malignant progression. Here, we deconvolute the human pancreatic TME through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models. We discover subTMEs,histologically definable tissue states anchored in fibroblast plasticity, with regional relationships to tumor immunity, subtypes, differentiation, and treatment response. ReactivesubTMEs rich in complex but functionally coordinated fibroblast communities were immune hot and inhabited by aggressive tumor cell phenotypes. The matrix-rich desertedsubTMEs harbored fewer activated fibroblasts and tumor-suppressive features yet were markedly chemoprotective and enriched upon chemotherapy. SubTMEs originated in fibroblast differentiation trajectories, and transitory states were notable both in single cell transcriptomics and in situ. The intratumoral co-occurrence of subTMEs produced patient-specific phenotypic and computationally predictable heterogeneity tightly linked to malignant biology. Therefore, heterogeneity within the plentiful, notorious pancreatic TME is not random but marks fundamental tissue organizational units.
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000713274500001
WOS关键词	HETEROGENEITY ; EXPRESSION ; SIGNATURES ; HALLMARK ; FEATURES ; SUBTYPES ; MODELS ; MOUSE
WOS类目	Biochemistry & Molecular Biology ; Cell Biology
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/368078
作者单位	[Grunwald, Barbara T.; Vyas, Foram; Aliar, Kazeera; McCloskey, Curtis W.; Macklin, Andrew; Notta, Faiyaz; Kislinger, Thomas; Khokha, Rama] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada; [Devisme, Antoine; Andrieux, Geoffroy; Boerries, Melanie] Univ Freiburg, Med Ctr Univ Freiburg, Fac Med, Inst Med Bioinformat & Syst Med, D-79110 Freiburg, Germany; [Devisme, Antoine] Univ Freiburg, Fac Biol, D-79110 Freiburg, Germany; [Andrieux, Geoffroy; Boerries, Melanie] German Canc Consortium DKTK, D-79110 Freiburg, Germany; [Andrieux, Geoffroy; Boerries, Melanie] German Canc Res Ctr, Partner Site Freiburg, D-79110 Freiburg, Germany; [Vyas, Foram; Notta, Faiyaz; Kislinger, Thomas; Khokha, Rama] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada; [Jang, Gun Ho; Denroche, Robert; Romero, Joan Miguel; Bavi, Prashant; Notta, Faiyaz; O'Kane, Grainne; Wilson, Julie; Knox, Jennifer; Gallinger, Steven] Ontario Inst Canc Res, PanCuRx Translat Res Initiat, Toronto, ON M5G 0A3, Canada; [Bavi...
推荐引用方式 GB/T 7714	Grunwald, Barbara T.,Devisme, Antoine,Andrieux, Geoffroy,et al. Spatially confined sub-tumor microenvironments in pancreatic cancer[J],2021,184(22):5577-+.
APA	Grunwald, Barbara T..,Devisme, Antoine.,Andrieux, Geoffroy.,Vyas, Foram.,Aliar, Kazeera.,...&Khokha, Rama.(2021).Spatially confined sub-tumor microenvironments in pancreatic cancer.CELL,184(22),5577-+.
MLA	Grunwald, Barbara T.,et al."Spatially confined sub-tumor microenvironments in pancreatic cancer".CELL 184.22(2021):5577-+.