干旱区生态环境知识资源中心(Arid): Gonadal Differentiation During Embryonic and Fetal Development of Male New Zealand Rabbits (Oryctolagus cuniculus)

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	Gonadal Differentiation During Embryonic and Fetal Development of Male New Zealand Rabbits (Oryctolagus cuniculus)
	Figueiredo de Carvalho Miranda, Carla Maria; Pereira Campos Leonel, Luciano Cesar; Aguiar Koga, Bruna Andrade; de Almeida da Anunciacao, Adriana Raquel; Mario, Lara Carolina; Favaron, Phelipe Oliveira; Martins, Daniele dos Santos; Vasquez, Belgica; Conei, Daniel; Miglino, Maria Angelica; del Sol, Mariano
通讯作者	Vasquez, B (corresponding author), Univ Tarapaca, Fac Hlth Sci, Iquique, Chile.
来源期刊	INTERNATIONAL JOURNAL OF MORPHOLOGY
ISSN	0717-9502
EISSN	0717-9367
出版年	2021
卷号	39 期号:5 页码:1253-1263
英文摘要	The rabbit is considered an ideal animal model for studies that describe abnormalities in the testicles due to the similar morphogenetic mechanisms of sexual development and diseases commonly found in humans. The aim of this study was to determine the male sexual differentiation of the New Zealand rabbit (Oryctolagus cuniculus) through development. The gestational age was estimated and classified as 9, 12, 14, 16, 18, 20, 23 and 28 gestational days. The morphological and sexual determination were performed by histological analysis of the reproductive tract in the embryos and fetuses (9-28 days) as well as by immunohistochemistry-Desert hedgehog-Dhh- (testis-specific protein on Y chromosome- 16, 20, 23 days and adult rabbits). Gonads were observed from the 14th day in an undifferentiated stage and with homogeneous aspect. Sexual differentiation was observed from the 16th day with presence of cells forming gonadal cords and Dhh(+) cells in the gonadal parenchyma. From the 18th gestational day testicular cords were observed, which evolved into organized seminiferous tubules. The formation of the efferent ducts and ductus deferens and epididymis was observed on the 20th and 23rd days, respectively. The differentiation of the external genitalia occurred from the 23rd days from the anogenital distance and was identified to identify the penile structures. In summary, the features of the sexual differentiation were determined by observation of the Dhh(+) protein in embryos from the 16th day to adulthood, and the morphological particularities observed from the 18th gestational day, determined by differentiation of the external genitalia from the 23rd day.
英文关键词	Gonads Embryonic development Seminiferous tubules Desert hedgehog Sustentacular cells Primordial germ cells
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000712329700001
WOS关键词	TESTICULAR DYSGENESIS SYNDROME ; ANOGENITAL DISTANCE ; GERM ; TESTES ; CELLS
WOS类目	Anatomy & Morphology
WOS研究方向	Anatomy & Morphology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/368015
作者单位	[Figueiredo de Carvalho Miranda, Carla Maria; Pereira Campos Leonel, Luciano Cesar; Aguiar Koga, Bruna Andrade; de Almeida da Anunciacao, Adriana Raquel; Mario, Lara Carolina; Favaron, Phelipe Oliveira; Miglino, Maria Angelica] Univ Sao Paulo, Sch Vet Med & Anim Sci, Sao Paulo, Brazil; [Figueiredo de Carvalho Miranda, Carla Maria; de Almeida da Anunciacao, Adriana Raquel; Mario, Lara Carolina; del Sol, Mariano] Univ La Frontera, Ctr Excellence Morphol & Surg Studies, Temuco, Chile; [Martins, Daniele dos Santos] Univ Sao Paulo, Fac Anim Sci & Food Engn, Pirassununga, SP, Brazil; [Vasquez, Belgica] Univ Tarapaca, Fac Hlth Sci, Iquique, Chile; [Conei, Daniel] Univ Aysen, Dept Hlth Sci, Coyhaique, Chile; [del Sol, Mariano] Univ La Frontera, Doctorate Program Morphol Sci, Temuco, Chile
推荐引用方式 GB/T 7714	Figueiredo de Carvalho Miranda, Carla Maria,Pereira Campos Leonel, Luciano Cesar,Aguiar Koga, Bruna Andrade,et al. Gonadal Differentiation During Embryonic and Fetal Development of Male New Zealand Rabbits (Oryctolagus cuniculus)[J],2021,39(5):1253-1263.
APA	Figueiredo de Carvalho Miranda, Carla Maria.,Pereira Campos Leonel, Luciano Cesar.,Aguiar Koga, Bruna Andrade.,de Almeida da Anunciacao, Adriana Raquel.,Mario, Lara Carolina.,...&del Sol, Mariano.(2021).Gonadal Differentiation During Embryonic and Fetal Development of Male New Zealand Rabbits (Oryctolagus cuniculus).INTERNATIONAL JOURNAL OF MORPHOLOGY,39(5),1253-1263.
MLA	Figueiredo de Carvalho Miranda, Carla Maria,et al."Gonadal Differentiation During Embryonic and Fetal Development of Male New Zealand Rabbits (Oryctolagus cuniculus)".INTERNATIONAL JOURNAL OF MORPHOLOGY 39.5(2021):1253-1263.