干旱区生态环境知识资源中心(Arid): Blinding practices during acute point-of-care ultrasound research: the BLIND-US meta-research study

Arid

DOI	10.1136/bmjebm-2020-111577
	Blinding practices during acute point-of-care ultrasound research: the BLIND-US meta-research study
	Prager, Ross; Wu, Kay; Bachar, Roudi; Unni, Rudy R.; Bowdridge, Joshua; McGrath, Trevor A.; Thavanathan, Rajiv; Woo, Michael Y.; McInnes, Matthew D. F.
通讯作者	Prager, R (corresponding author), Univ Ottawa, Dept Med, Ottawa, ON, Canada.
来源期刊	BMJ EVIDENCE-BASED MEDICINE
ISSN	2515-446X
EISSN	2515-4478
出版年	2021
卷号	26 期号:3 页码:110-+
英文摘要	Objectives Point-of-care ultrasound (POCUS) diagnostic accuracy research has significant variation in blinding practices. This study characterises the blinding practices during acute POCUS research to determine whether research methodology adequately reflects POCUS use in routine clinical practice. Design, settings and participants A search for POCUS diagnostic accuracy studies published in Emergency Medicine, Anaesthesia arid Critical Care journals from January 2016 to January 2020 was perfonned. Studies were included if they were primary diagnostic accuracy studies. The study year, journal impact factor, population, hospital area, body region, study design, blinding of the POCUS interpreter to clinical information, whether the person performing the POCUS scan was the same person interpreting the scan, and whether the study reported incremental diagnostic yield were extracted in duplicate by two authors. Descriptive statistics were provided and prespecified subgroup analysis was performed. Main outcome measures The primary outcome was the number of studies that blinded the POCUS interpreter to at least some part of the clinical infonnation. Secondary outcomes included whether the person performing the POCUS scan was the same person interpreting it and whether the study reported incremental diagnostic yield. Results 520 abstracts were screened with 97 studies included. The POCUS interpreter was blinded to clinical information in 37 studies (38.1%), not blinded in 34 studies (35.1%) and not reported in 26 studies (26.8%). The POCUS interpreter was the same person obtaining the images in 72 studies (74.2%), different in 14 studies (14.4%) and not reported in 11 studies (11.3%). Only four studies (4.14b) reported incremental diagnostic yield for POCUS. Interrater reliability was moderate (k=0.64). Subgroup analysis based on impact factor, body region, hospital area, patient population and study design did not show significant differences after completing pairwise comparisons. Conclusions Although blinding the POCUS interpreter to clinical information may be done in a perceived attempt to limit bias, this may result in accuracy estimates that do not reflect routine clinical practice. Similarly, having a different clinician perform and interpret the POCUS scan significantly limits generalisability to practice as it does not truly reflect 'point-of-care' ultrasound at all. Reporting incremental diagnostic yield from implementing POCUS into a diagnostic pathway better reflects the value of POCUS; however, this methodology was infrequently used.
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000656481900013
WOS关键词	DIAGNOSTIC PERFORMANCE ; CLINICAL INFORMATION ; ACCURACY ; BIAS
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/367811
作者单位	[Prager, Ross; Unni, Rudy R.; Bowdridge, Joshua] Univ Ottawa, Dept Med, Ottawa, ON, Canada; [Wu, Kay] McMaster Univ, Fac Med, Hamilton, ON, Canada; [Bachar, Roudi] Wrexham Maelor Hosp, Wrexham, Wales; [McGrath, Trevor A.; McInnes, Matthew D. F.] Univ Ottawa, Dept Radiol, Ottawa, ON, Canada; [Thavanathan, Rajiv; Woo, Michael Y.] Univ Ottawa, Dept Emergency Med, Ottawa, ON, Canada; [McInnes, Matthew D. F.] Univ Ottawa, Dept Epidemiol, Ottawa, ON, Canada
推荐引用方式 GB/T 7714	Prager, Ross,Wu, Kay,Bachar, Roudi,et al. Blinding practices during acute point-of-care ultrasound research: the BLIND-US meta-research study[J],2021,26(3):110-+.
APA	Prager, Ross.,Wu, Kay.,Bachar, Roudi.,Unni, Rudy R..,Bowdridge, Joshua.,...&McInnes, Matthew D. F..(2021).Blinding practices during acute point-of-care ultrasound research: the BLIND-US meta-research study.BMJ EVIDENCE-BASED MEDICINE,26(3),110-+.
MLA	Prager, Ross,et al."Blinding practices during acute point-of-care ultrasound research: the BLIND-US meta-research study".BMJ EVIDENCE-BASED MEDICINE 26.3(2021):110-+.