干旱区生态环境知识资源中心(Arid): Diversity,novelty,antimicrobial activity,and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert

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	Diversity,novelty,antimicrobial activity,and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert
	Wang Ting; Li Feina; Lu Qinpei; Wu Gang; Jiang Zhongke; Liu Shaowei; Habden Xugela; Razumova Elizaveta A; Osterman Ilya A; Sergiev Petr V; Dontsova Olga A; Hu Xinxin; You Xuefu; Sun Chenghang
来源期刊	药物分析学报
ISSN	2095-1779
出版年	2021
卷号	11 期号:2 页码:2095-1779
英文摘要	Three hundred and twenty endophytic actinobacterial strains were isolated from psammophytes collected from Taklamakan Desert and identified.Among them,three strains already had been identified as new species of two genera and sixteen isolates showed relatively low 16S rRNA similarities <98.6% to validly described species.Seventy-five of the isolates were selected as representative strains to screen antibacterial activity and mechanism.Forty-seven strains showed antagonistic activity against at least one of the indicator bacteria.Two Streptomyces strains produced bioactive compounds inducing DNA damage,and two Streptomyces strains produced bioactive compounds with inhibitory activity on protein biosynthesis.Notably,the strain Streptomyces sp.8P21H-1 that demonstrated both strong antibacterial activity and inhibitory activity on protein biosynthesis was prioritized for exploring new antibiotics.Under the strategy of integrating genetics-based discovery program and MS/MS-based molecular networking,two new streptogramin-type antibiotics,i.e.,acetyl-griseoviridin and desulphurizing griseoviridin,along with known griseoviridin,were isolated from the culture broth of strain 8P21H-1.Their chemical structures were determined by HR-MS,and 1D and 2D NMR.Desulphurizing griseoviridin and griseoviridin exhibited antibacterial activities by inhibiting translation.
英文关键词	Taklamakan desert Endophytic actinobacteria Novelty Diversity Streptogramin-type antibiotic
类型	Article
语种	英语
国家	中国
开放获取类型	gold, Green Published
收录类别	CSCD
WOS类目	Pharmacology & Pharmacy
CSCD记录号	CSCD:6964879
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/365363
作者单位	Wang Ting, Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College;;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College, ;;Beijing Key Laboratory of Antimicrobial Agents, ;;, Beijing;;Beijing 100050;;100050.; Li Feina, Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College;;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College, ;;Beijing Key Laboratory of Antimicrobial Agents, ;;, Beijing;;Beijing 100050;;100050.; Lu Qinpei, Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College;;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College, ;;Beijing Key Laboratory of Antimicrobial Agents, ;;, Beijing;;Beijing 100050;;100050.; Wu Gang, Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Uni...
推荐引用方式 GB/T 7714	Wang Ting,Li Feina,Lu Qinpei,et al. Diversity,novelty,antimicrobial activity,and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert[J],2021,11(2):2095-1779.
APA	Wang Ting.,Li Feina.,Lu Qinpei.,Wu Gang.,Jiang Zhongke.,...&Sun Chenghang.(2021).Diversity,novelty,antimicrobial activity,and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert.药物分析学报,11(2),2095-1779.
MLA	Wang Ting,et al."Diversity,novelty,antimicrobial activity,and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert".药物分析学报 11.2(2021):2095-1779.