干旱区生态环境知识资源中心(Arid): Landscape genomics and selection signatures of local adaptation of Eritrean indigenous cattle along environmental gradients

Arid

DOI	10.1007/s11250-021-02837-6
	Landscape genomics and selection signatures of local adaptation of Eritrean indigenous cattle along environmental gradients
	Goitom, S.; Gicheha, Mathew G.; Njonge, Francis K.; Kiplangat, Ngeno
通讯作者	Gicheha, MG (corresponding author), Jomo Kenyatta Univ Agr & Technol, Dept Anim Sci, POB 62000-00200, Nairobi, Kenya.
来源期刊	TROPICAL ANIMAL HEALTH AND PRODUCTION
ISSN	0049-4747
EISSN	1573-7438
出版年	2021
卷号	53 期号:4
英文摘要	Most parts of Eritrea are classified as arid and semi-arid land (ASALs) which are characterised by dryness, high ambient temperatures and low precipitation. The country has three different environmental landscapes: highland, Western lowland and Eastern lowland agro-ecological zones (AEZs). The geophysical and biophysical characteristics of the AEZs vary. Indigenous cattle which are mainly kept in extensive production system have to cope with the adverse climatic conditions of these AEZs. They have to adapt to the harsh climate, poor feed quality and endemic diseases and parasites and reproduction challenges in the AEZs. The underlying genetic basis of the indigenous cattle adaption to the specific AEZs in Eritrea is limited. In this study, it is hypothesized that the indigenous cattle have evolved and developed unique adaptive characteristics because of being reared in specific ecological landscapes. This was tested using the landscape genomics and analysis of selection signatures to ascertain the genetic basis of their adaptability to the nutritional and environmental constraints that characterise the AEZ conditions. The study was carried out in three different environmental landscapes: highland, Eastern lowland and Western lowland AEZs. Blood samples were collected from a total of 188 indigenous cattle populations sampled from the three AEZs. DNA was extracted and genotyped using the genotype by sequencing (GBS) method. Analysis revealed the existence of medium to high genetic diversity between and within the indigenous cattle populations. Scanning of selection signatures revealed genomic regions under positive selection. The regions harboured genes (IFNAR2, CASR, AHSG, ATP1B3, AIRE, ROBO2, SCHIP1 and PARS2) of importance for facial morphology, locomotion, mineral homeostasis, immune system and skeletal and muscle system development. Findings pointed out the influence of AEZ landscapes on the genetic differentiation of indigenous cattle appearances probably due to selection driven by diverse climatic and biophysical conditions. The differentiation is orientated towards adaptive characteristics.
英文关键词	Adaptive Geographical barriers Isolation by distance Single-nucleotide polymorphisms
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000679787500001
WOS关键词	GENETICS
WOS类目	Agriculture, Dairy & Animal Science ; Veterinary Sciences
WOS研究方向	Agriculture ; Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364803
作者单位	[Goitom, S.] Hamelmalo Agr Coll, Dept Anim Sci, Keren, Eritrea; [Gicheha, Mathew G.; Njonge, Francis K.] Jomo Kenyatta Univ Agr & Technol, Dept Anim Sci, POB 62000-00200, Nairobi, Kenya; [Kiplangat, Ngeno] Egerton Univ, Dept Anim Sci, POB 635, Njoro, Kenya
推荐引用方式 GB/T 7714	Goitom, S.,Gicheha, Mathew G.,Njonge, Francis K.,et al. Landscape genomics and selection signatures of local adaptation of Eritrean indigenous cattle along environmental gradients[J],2021,53(4).
APA	Goitom, S.,Gicheha, Mathew G.,Njonge, Francis K.,&Kiplangat, Ngeno.(2021).Landscape genomics and selection signatures of local adaptation of Eritrean indigenous cattle along environmental gradients.TROPICAL ANIMAL HEALTH AND PRODUCTION,53(4).
MLA	Goitom, S.,et al."Landscape genomics and selection signatures of local adaptation of Eritrean indigenous cattle along environmental gradients".TROPICAL ANIMAL HEALTH AND PRODUCTION 53.4(2021).