干旱区生态环境知识资源中心(Arid): Quantification of selected analgesics and their metabolites in influent wastewater by liquid chromatography tandem mass spectrometry

Arid

DOI	10.1016/j.talanta.2021.122627
	Quantification of selected analgesics and their metabolites in influent wastewater by liquid chromatography tandem mass spectrometry
	Ahmed, Fahad; Tscharke, Benjamin; O'Brien, Jake W.; Thompson, Jack; Zheng, Qiuda; Mueller, Jochen F.; Thomas, Kevin, V
通讯作者	Ahmed, F (corresponding author), Univ Queensland, Queensland Alliance Environm Hlth Sci QAEHS, Woolloongabba, Qld 4102, Australia.
来源期刊	TALANTA
ISSN	0039-9140
EISSN	1873-3573
出版年	2021
卷号	234
英文摘要	Wastewater-based epidemiology (WBE) is an established tool to analyse patterns of community drug use. In recent times, monitoring the use of analgesics has become a public health priority. An analytical method was developed, optimised and validated for a broad range of common analgesics (non-steroidal anti-inflammatories and opioids) and their metabolites at trace concentrations in wastewater influent. Samples were analysed via liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with an electrospray ionization source (ESI) in both positive and negative ion multiple reaction monitoring modes. Fifteen of the thirty-five biomarkers were validated for LC-MS/MS analysis by direct injection, while the other 20 biomarkers were present in wastewater at lower concentrations, requiring extraction by solid phase extraction (SPE) using Oasis HLB cartridges. The limit of quantification (LOQ) ranged between 17 ng/L - 191 ng/L and 13 ng/L -110 ng/L for direct injection and SPE, respectively. Recoveries for SPE ranged between 80% and 120%. Following validation, the method was applied to 28 wastewater samples from four municipal wastewater treatment plants. Twenty-eight of the thirty-five analgesic biomarkers were detected in the samples at concentrations of between 0.03 and 289 mu g/L. Population normalised mass loads ranged from 10 mg/day/1000 (meperidine) to 72,000 mg/day/1000 (paracetamol) among all investigated compounds. The described method is a suitable analytical tool for wastewater-based epidemiology applications to estimate analgesics consumption.
英文关键词	NSAIDs Opioids Pain LC-MS/MS Wastewater-based epidemiology
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000687342200011
WOS关键词	CONSUMPTION ; OPIOIDS ; DRUGS
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364775
作者单位	[Ahmed, Fahad; Tscharke, Benjamin; O'Brien, Jake W.; Thompson, Jack; Zheng, Qiuda; Mueller, Jochen F.; Thomas, Kevin, V] Univ Queensland, Queensland Alliance Environm Hlth Sci QAEHS, Woolloongabba, Qld 4102, Australia
推荐引用方式 GB/T 7714	Ahmed, Fahad,Tscharke, Benjamin,O'Brien, Jake W.,et al. Quantification of selected analgesics and their metabolites in influent wastewater by liquid chromatography tandem mass spectrometry[J],2021,234.
APA	Ahmed, Fahad.,Tscharke, Benjamin.,O'Brien, Jake W..,Thompson, Jack.,Zheng, Qiuda.,...&Thomas, Kevin, V.(2021).Quantification of selected analgesics and their metabolites in influent wastewater by liquid chromatography tandem mass spectrometry.TALANTA,234.
MLA	Ahmed, Fahad,et al."Quantification of selected analgesics and their metabolites in influent wastewater by liquid chromatography tandem mass spectrometry".TALANTA 234(2021).