干旱区生态环境知识资源中心(Arid): The Desert Hedgehog Signalling Pathway in Human Gonadal Development and Differences of Sex Development

Arid

DOI	10.1159/000518308
	The Desert Hedgehog Signalling Pathway in Human Gonadal Development and Differences of Sex Development
	Pachernegg, Svenja; Georges, Elizabeth; Ayers, Katie
通讯作者	Ayers, K (corresponding author), Murdoch Childrens Res Inst, Reprod Dev Grp, Melbourne, Vic, Australia. ; Ayers, K (corresponding author), Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia.
来源期刊	SEXUAL DEVELOPMENT
ISSN	1661-5425
EISSN	1661-5433
出版年	2021-09
英文摘要	While the Hedgehog signalling pathway is implicated in numerous developmental processes and maladies, variants in the Desert Hedgehog (DHH) ligand underlie a condition characterised by 46,XY gonadal dysgenesis with or without peripheral neuropathy. We discuss here the role and regulation of DHH and its signalling pathway in the developing gonads and examine the current understanding of how disruption to this pathway causes this difference of sex development (DSD) in humans.
英文关键词	Desert hedgehog Differences of sex development Gonadal dysgenesis Testis development
类型	Review ; Early Access
语种	英语
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000695746500001
WOS关键词	LEYDIG-LIKE CELLS ; EMBRYONIC STEM-CELLS ; SONIC HEDGEHOG ; DHH GENE ; CHOLESTEROL MODIFICATION ; MINIFASCICLE FORMATION ; LIPID MODIFICATIONS ; EXPRESSION ; TESTIS ; DYSGENESIS
WOS类目	Developmental Biology
WOS研究方向	Developmental Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364688
作者单位	[Pachernegg, Svenja; Ayers, Katie] Murdoch Childrens Res Inst, Reprod Dev Grp, Melbourne, Vic, Australia; [Pachernegg, Svenja; Georges, Elizabeth; Ayers, Katie] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
推荐引用方式 GB/T 7714	Pachernegg, Svenja,Georges, Elizabeth,Ayers, Katie. The Desert Hedgehog Signalling Pathway in Human Gonadal Development and Differences of Sex Development[J],2021.
APA	Pachernegg, Svenja,Georges, Elizabeth,&Ayers, Katie.(2021).The Desert Hedgehog Signalling Pathway in Human Gonadal Development and Differences of Sex Development.SEXUAL DEVELOPMENT.
MLA	Pachernegg, Svenja,et al."The Desert Hedgehog Signalling Pathway in Human Gonadal Development and Differences of Sex Development".SEXUAL DEVELOPMENT (2021).