干旱区生态环境知识资源中心(Arid): Reversible insulin resistance helps Bactrian camels survive fasting

Arid

DOI	10.1038/s41598-021-98234-y
	Reversible insulin resistance helps Bactrian camels survive fasting
	Guo, Fucheng; Si, Rendalai; Li, Quanyun; Hai, Le; Yi, Li; He, Jing; Ming, Liang; Ji, Rimutu
通讯作者	Ming, L ; Ji, R (corresponding author), Inner Mongolia Agr Univ, Coll Food Sci & Engn, Key Lab Dairy Biotechnol & Bioengn, Minist Educ, Hohhot 010018, Peoples R China. ; Ji, R (corresponding author), Camel Res Inst Inner Mongolia, Alxa 737300, Peoples R China.
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2021
卷号	11 期号:1
英文摘要	Camels have hunger tolerance and can adapt to the severe environment of the desert. Through the comparison of insulin signalling pathway genes in different tissues in different eating periods (feeding, fasting and recovery feeding), it was found that IRS1, PIK3CB, PIK3R1 and SLC2A4 expression was significantly downregulated in the fore hump and hind hump during the fasting period. In addition, there was no difference in serum insulin levels among the three stages. However, the serum leptin and adiponectin levels decreased significantly during fasting. Additionally, insulin tolerance tests during the three stages showed that camels were insensitive to insulin during fasting. Further study of the serum metabolites showed that serum branched-chain and aromatic amino acid levels increased during the fasting period. Finally, analysis of microbial diversity in camel faeces at different stages showed that during the fasting period, the proportion of Firmicutes and Actinobacteria increased, while that of Bacteroides and the butyrate-producing bacterium Roseburia decreased. The results of this study show that fasting is accompanied by changes in the activation of insulin pathways in various camel tissues, normal insulin levels, and increased lipolysis and insulin resistance, which return to normal after eating.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000700297100053
WOS关键词	CHAIN AMINO-ACIDS ; BRANCHED-CHAIN ; GENE-EXPRESSION ; GUT MICROBIOME ; OBESITY ; ADIPONECTIN ; SENSITIVITY ; GLUCOSE ; METABOLISM ; METAGENOME
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364674
作者单位	[Guo, Fucheng; Si, Rendalai; Li, Quanyun; Hai, Le; Yi, Li; He, Jing; Ming, Liang; Ji, Rimutu] Inner Mongolia Agr Univ, Coll Food Sci & Engn, Key Lab Dairy Biotechnol & Bioengn, Minist Educ, Hohhot 010018, Peoples R China; [Si, Rendalai; Ji, Rimutu] Camel Res Inst Inner Mongolia, Alxa 737300, Peoples R China
推荐引用方式 GB/T 7714	Guo, Fucheng,Si, Rendalai,Li, Quanyun,et al. Reversible insulin resistance helps Bactrian camels survive fasting[J],2021,11(1).
APA	Guo, Fucheng.,Si, Rendalai.,Li, Quanyun.,Hai, Le.,Yi, Li.,...&Ji, Rimutu.(2021).Reversible insulin resistance helps Bactrian camels survive fasting.SCIENTIFIC REPORTS,11(1).
MLA	Guo, Fucheng,et al."Reversible insulin resistance helps Bactrian camels survive fasting".SCIENTIFIC REPORTS 11.1(2021).