干旱区生态环境知识资源中心(Arid): Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI

Arid

DOI	10.1038/s41598-021-82187-3
	Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI
	Shahid, Syed Salman; Kerskens, Christian M.; Burrows, Malcolm; Witney, Alice G.
通讯作者	Witney, AG (corresponding author), Trinity Coll Dublin, Trinity Biomed Sci Inst, Trinity Ctr Biomed Engn, Dept Physiol,Trinity Coll Inst Neurosci,Sch Med, Dublin 2, Ireland.
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2021
卷号	11 期号:1
英文摘要	To understand brain function it is necessary to characterize both the underlying structural connectivity between neurons and the physiological integrity of these connections. Previous research exploring insect brain connectivity has typically used electron microscopy techniques, but this methodology cannot be applied to living animals and so cannot be used to understand dynamic physiological processes. The relatively large brain of the desert locust, Schistercera gregaria (Forksal) is ideal for exploring a novel methodology; micro diffusion magnetic resonance imaging (micro-dMRI) for the characterization of neuronal connectivity in an insect brain. The diffusion-weighted imaging (DWI) data were acquired on a preclinical system using a customised multi-shell diffusion MRI scheme optimized to image the locust brain. Endogenous imaging contrasts from the averaged DWIs and Diffusion Kurtosis Imaging (DKI) scheme were applied to classify various anatomical features and diffusion patterns in neuropils, respectively. The application of micro-dMRI modelling to the locust brain provides a novel means of identifying anatomical regions and inferring connectivity of large tracts in an insect brain. Furthermore, quantitative imaging indices derived from the kurtosis model that include fractional anisotropy (FA), mean diffusivity (MD) and kurtosis anisotropy (KA) can be extracted. These metrics could, in future, be used to quantify longitudinal structural changes in the nervous system of the locust brain that occur due to environmental stressors or ageing.
类型	Article
语种	英语
开放获取类型	Green Published, Green Submitted, gold
收录类别	SCI-E
WOS记录号	WOS:000684871300006
WOS关键词	DIFFUSION-WEIGHTED MRI ; WATER DIFFUSION ; NERVOUS-SYSTEM ; IN-VIVO ; BEHAVIORAL GREGARIZATION ; DESERT LOCUST ; KURTOSIS ; PARAMETERS ; BRAIN
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364667
作者单位	[Shahid, Syed Salman] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA; [Kerskens, Christian M.] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Sch Med, Trinity Ctr Biomed Engn, Dublin 2, Ireland; [Burrows, Malcolm] Univ Cambridge, Dept Zool, Cambridge, England; [Witney, Alice G.] Trinity Coll Dublin, Trinity Biomed Sci Inst, Trinity Ctr Biomed Engn, Dept Physiol,Trinity Coll Inst Neurosci,Sch Med, Dublin 2, Ireland
推荐引用方式 GB/T 7714	Shahid, Syed Salman,Kerskens, Christian M.,Burrows, Malcolm,et al. Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI[J],2021,11(1).
APA	Shahid, Syed Salman,Kerskens, Christian M.,Burrows, Malcolm,&Witney, Alice G..(2021).Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI.SCIENTIFIC REPORTS,11(1).
MLA	Shahid, Syed Salman,et al."Elucidating the complex organization of neural micro-domains in the locust Schistocerca gregaria using dMRI".SCIENTIFIC REPORTS 11.1(2021).