干旱区生态环境知识资源中心(Arid): Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment

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DOI	10.1016/j.oraloncology.2021.105420
	Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment
	Farlow, Janice L.; Brenner, J. Chad; Lei, Yu L.; Chinn, Steven B.
通讯作者	Chinn, SB (corresponding author), Michigan Med, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA. ; Chinn, SB (corresponding author), Michigan Med, Rogel Canc Ctr, Ann Arbor, MI 48109 USA.
来源期刊	ORAL ONCOLOGY
ISSN	1368-8375
EISSN	1879-0593
出版年	2021
卷号	120
英文摘要	Immunotherapy revolutionized cancer treatment but has yet to elicit durable responses in the majority of patients with head and neck squamous cell carcinoma (HNSCC). HNSCC is generally characterized by a high tumor mutational burden, which has translated to a large neoantigen load that could prime the immune system to recognize and eliminate malignant cells. Studies are increasingly showing, however, that HNSCC is an immune desert tumor that can hijack multiple parts of the tumor immunity cycle in order to evade immune recognition and suppress immune system activation. Herein we will review how HNSCC tumors modulate their architecture, cellular composition, and cytokine milieu to maximize immunosuppression; as well as relevant therapeutic opportunities and emerging issues facing the field of HNSCC immuno-oncology.
英文关键词	Head and neck cancer Squamous cell carcinoma Cancer immunology Tumor microenvironment Antigenicity Immunogenicity Immunotherapy Immune desert Immune evasion Immunosuppression
类型	Review
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000688349800009
WOS关键词	REGULATORY T-CELLS ; ANTIGEN-PROCESSING MACHINERY ; ANTITUMOR IMMUNITY ; IMMUNOSUPPRESSIVE MICROENVIRONMENT ; INFILTRATING LYMPHOCYTES ; ADAPTIVE IMMUNITY ; SUPPRESSOR-CELLS ; PD-L1 EXPRESSION ; OPEN-LABEL ; IN-VITRO
WOS类目	Oncology ; Dentistry, Oral Surgery & Medicine
WOS研究方向	Oncology ; Dentistry, Oral Surgery & Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364268
作者单位	[Farlow, Janice L.; Brenner, J. Chad; Lei, Yu L.; Chinn, Steven B.] Michigan Med, Dept Otolaryngol Head & Neck Surg, Ann Arbor, MI 48109 USA; [Brenner, J. Chad; Lei, Yu L.; Chinn, Steven B.] Michigan Med, Rogel Canc Ctr, Ann Arbor, MI 48109 USA; [Lei, Yu L.] Michigan Med, Dept Periodont & Oral Med, Ann Arbor, MI USA
推荐引用方式 GB/T 7714	Farlow, Janice L.,Brenner, J. Chad,Lei, Yu L.,et al. Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment[J],2021,120.
APA	Farlow, Janice L.,Brenner, J. Chad,Lei, Yu L.,&Chinn, Steven B..(2021).Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment.ORAL ONCOLOGY,120.
MLA	Farlow, Janice L.,et al."Immune deserts in head and neck squamous cell carcinoma: A review of challenges and opportunities for modulating the tumor immune microenvironment".ORAL ONCOLOGY 120(2021).