干旱区生态环境知识资源中心(Arid): Autologous tumor antigens and boron nanosheet-based nanovaccines for enhanced photo-immunotherapy against immune desert tumors

Arid

DOI	10.1515/nanoph-2021-0229
	Autologous tumor antigens and boron nanosheet-based nanovaccines for enhanced photo-immunotherapy against immune desert tumors
	Sun, Zhe; Fan, Taojian; Liu, Quan; Huang, Luodan; Hu, Weibin; Shi, Lulin; Wu, Zongze; Yang, Qinhe; Liu, Liping; Zhang, Han
通讯作者	Zhang, H (corresponding author), Shenzhen Univ, Inst Microscale Optoelect,Collaborat Innovat Ctr, Minist Educ & Guangdong Prov,Key Lab Optoelect De, Coll Phys & Optoelect Engn,Shenzhen Key Lab Micro, Shenzhen 518060, Peoples R China. ; Liu, LP (corresponding author), Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Hepatobiliary & Pancreat Surg, Shenzhen 518020, Peoples R China. ; Yang, QH (corresponding author), Jinan Univ, Sch Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China.
来源期刊	NANOPHOTONICS
ISSN	2192-8606
EISSN	2192-8614
出版年	2021
卷号	10 期号:9 页码:2519-2535
英文摘要	Personalized therapeutic vaccines against immune desert tumors are an increasingly important field in current cancer immunotherapy. However, limitations in neoantigen recognition, impotent immune cells, and a lack of intratumoral infiltrated lymphocytes pose challenges for the cancer vaccines. Resected tumors contain various of patient-specific tumor autoantigens (TA), and its derived photonanovaccines have unique competency to overcome abovementioned barriers. We constructed a novel personalized photonanovaccine (B@TA-R848) with surgically sourced TA modified on two-dimensional boron nanosheets (BNSs) via polydopamine coating and loaded with immune adjuvant R848. B@TA-R848 has good properties of drug delivery and release, photoacoustic imaging, photothermal effect, and biocompatibility. In a mouse triple-negative breast cancer model, B@TA-R848-based photonanovaccine induced effective systemic antitumor immune responses, altered the local tumor microenvironment, and increased the intratumoral infiltration of immune cells. The combined photo immunotherapy could significantly inhibit tumor growth, recurrence, and metastasis. This work develops a novel photonanovaccine for low immunogenicity and high metastatic potential tumors, which is of great significance for exploring the clinical development of personalized tumor vaccines against immune desert tumors.
英文关键词	2D boron nanosheet immunotherapy nanovaccine photothermal therapy tumor autoantigen
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000672600300017
WOS关键词	CANCER ; NANOPARTICLES ; VACCINES ; THERAPY
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Optics ; Physics, Applied
WOS研究方向	Science & Technology - Other Topics ; Materials Science ; Optics ; Physics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364209
作者单位	[Fan, Taojian; Zhang, Han] Shenzhen Univ, Inst Microscale Optoelect,Collaborat Innovat Ctr, Minist Educ & Guangdong Prov,Key Lab Optoelect De, Coll Phys & Optoelect Engn,Shenzhen Key Lab Micro, Shenzhen 518060, Peoples R China; [Sun, Zhe; Liu, Quan; Huang, Luodan; Hu, Weibin; Shi, Lulin; Wu, Zongze; Liu, Liping] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Hepatobiliary & Pancreat Surg, Shenzhen 518020, Peoples R China; [Sun, Zhe; Yang, Qinhe] Jinan Univ, Sch Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China; [Sun, Zhe] Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Sun, Zhe,Fan, Taojian,Liu, Quan,et al. Autologous tumor antigens and boron nanosheet-based nanovaccines for enhanced photo-immunotherapy against immune desert tumors[J],2021,10(9):2519-2535.
APA	Sun, Zhe.,Fan, Taojian.,Liu, Quan.,Huang, Luodan.,Hu, Weibin.,...&Zhang, Han.(2021).Autologous tumor antigens and boron nanosheet-based nanovaccines for enhanced photo-immunotherapy against immune desert tumors.NANOPHOTONICS,10(9),2519-2535.
MLA	Sun, Zhe,et al."Autologous tumor antigens and boron nanosheet-based nanovaccines for enhanced photo-immunotherapy against immune desert tumors".NANOPHOTONICS 10.9(2021):2519-2535.