干旱区生态环境知识资源中心(Arid): Associations between DNA methylation and telomere length during early life: Insight from wild zebra finches (Taeniopygia guttata)

Arid

DOI	10.1111/mec.16187
	Associations between DNA methylation and telomere length during early life: Insight from wild zebra finches (Taeniopygia guttata)
	Sheldon, Elizabeth L.; Ton, Riccardo; Boner, Winnie; Monaghan, Pat; Raveh, Shirley; Schrey, Aaron W.; Griffith, Simon C.
通讯作者	Sheldon, EL (corresponding author), Macquarie Univ, Dept Biol Sci, Sydney, NSW, Australia.
来源期刊	MOLECULAR ECOLOGY
ISSN	0962-1083
EISSN	1365-294X
出版年	2021-10
英文摘要	Telomere length and DNA methylation (DNAm) are two promising biomarkers of biological age. Environmental factors and life history traits are known to affect variation in both these biomarkers, especially during early life, yet surprisingly little is known about their reciprocal association, especially in natural populations. Here, we explore how variation in DNAm, growth rate, and early-life conditions are associated with telomere length changes during development. We tested these associations by collecting data from wild, nestling zebra finches in the Australian desert. We found that increases in the level of DNAm were negatively correlated with telomere length changes across early life. We also confirm previously documented effects of post hatch growth rate and clutch size on telomere length in a natural ecological context for a species that has been extensively studied in the laboratory. However, we did not detect any effect of ambient temperature during developmental on telomere length dynamics. We also found that the absolute telomere length of wild zebra finches, measured using the in-gel TRF method, was similar to that of captive birds. Our findings highlight exciting new opportunities to link and disentangle potential relationships between DNA based biomarkers of ageing, and of physiological reactions to environmental change.
英文关键词	ageing Aves biomarkers development life history temperature effects
类型	Article ; Early Access
语种	英语
开放获取类型	Green Submitted
收录类别	SCI-E
WOS记录号	WOS:000703599500001
WOS关键词	REPRODUCTIVE SUCCESS ; DYNAMICS ; STRESS ; SIZE ; SENESCENCE ; PATTERNS ; LONG
WOS类目	Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology
WOS研究方向	Biochemistry & Molecular Biology ; Environmental Sciences & Ecology ; Evolutionary Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364190
作者单位	[Sheldon, Elizabeth L.; Ton, Riccardo; Griffith, Simon C.] Macquarie Univ, Dept Biol Sci, Sydney, NSW, Australia; [Boner, Winnie; Monaghan, Pat; Raveh, Shirley] Univ Glasgow, Coll Med Vet & Life Sci, Inst Biodivers Anim Hlth & Comparat Med, Glasgow, Lanark, Scotland; [Schrey, Aaron W.] Georgia Southern Univ, Dept Biol, Armstrong Campus, Savannah, GA USA
推荐引用方式 GB/T 7714	Sheldon, Elizabeth L.,Ton, Riccardo,Boner, Winnie,et al. Associations between DNA methylation and telomere length during early life: Insight from wild zebra finches (Taeniopygia guttata)[J],2021.
APA	Sheldon, Elizabeth L..,Ton, Riccardo.,Boner, Winnie.,Monaghan, Pat.,Raveh, Shirley.,...&Griffith, Simon C..(2021).Associations between DNA methylation and telomere length during early life: Insight from wild zebra finches (Taeniopygia guttata).MOLECULAR ECOLOGY.
MLA	Sheldon, Elizabeth L.,et al."Associations between DNA methylation and telomere length during early life: Insight from wild zebra finches (Taeniopygia guttata)".MOLECULAR ECOLOGY (2021).