干旱区生态环境知识资源中心(Arid): Combating multidrug-resistant Staphylococcus aureus isolated from camel milk with extracts of Eucalyptus globulus and Calotropis procera, and their potential role in modulation of resistance to beta-lactam drugs

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DOI	10.21521/mw.6583
	Combating multidrug-resistant Staphylococcus aureus isolated from camel milk with extracts of Eucalyptus globulus and Calotropis procera, and their potential role in modulation of resistance to beta-lactam drugs
	Ali, Mahboob; Avais, Muhammad; Jamal, Muhammad Ameen; Ijaz, Muhammad; Chaudhry, Mamoona; Aqib, Amjad Islam; Khan, Mumtaz Ali; Ahmed, Mehtab; Hasni, Muhammad Sajid; Hameed, Sajid; Haq, Inzmam Ul
通讯作者	Avais, M (corresponding author), Univ Vet & Anim Sci, Dept Clin Med, Lahore 54000, Pakistan.
来源期刊	MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE
ISSN	0025-8628
出版年	2021
卷号	77 期号:10 页码:491-496
英文摘要	This study aimed to evaluate the efficacy of Eucalyptus globulus and Calotropis procera against MDRSA and their potential role in modulating resistance to beta-lactam drugs. The study used a total of n = 263 camel milk samples as well as aqueous and ethanolic extracts of both plants from the Cholistan Desert and the Suleman Mountain Range in Pakistan. Different concentrations of the two plants (25, 12.6, 6.25, and 3.125 mg/mL), either alone or in combination with each other, were tested against MDRSA by well diffusion and broth dilution methods. Further, the efficacy of both plant extracts in combination with cefotaxime (30 mu g) and ampicillin (1 mu g) was also tested. The results indicate that the zone of inhibition (ZOI) of E globulus alone and in combination with C. procera was nearly 3 times as large as that of C. procera. Ethanolic extracts of the two plants plants, alone or in combination with either of the two antibiotics, had a significantly (P < 0.05) larger ZOI than their aqueous extracts did. Further, the modulation factor for the drugs in combination with ethanolic extracts of both plants exhibited strong synergy (P <0.05), and the minimum inhibitory concentration (MIC) of ethanolic extracts was also significantly lower than that of the aqueous extract of either plant (P < 0.05). In conclusion, the ethanolic extracts of E. globulus and C. procera alone and in combination are effective against MDRSA and can play a role in modulating resistance to beta-lactam antibiotics.
英文关键词	drug resistance plant extracts Staphylococcus aureus beta-lactams
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000697686300004
WOS关键词	PLANT-EXTRACTS ; ANTIBIOTICS
WOS类目	Veterinary Sciences
WOS研究方向	Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364155
作者单位	[Ali, Mahboob; Avais, Muhammad; Ijaz, Muhammad; Khan, Mumtaz Ali] Univ Vet & Anim Sci, Dept Clin Med, Lahore 54000, Pakistan; [Jamal, Muhammad Ameen] Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Yunnan, Peoples R China; [Chaudhry, Mamoona; Hasni, Muhammad Sajid] Univ Vet & Anim Sci, Dept Epidemiol & Publ Hlth, Lahore 54000, Pakistan; [Aqib, Amjad Islam] Cholistan Univ Vet & Anim Sci, Bahawalpur, Pakistan; [Ali, Mahboob; Ahmed, Mehtab; Hasni, Muhammad Sajid] Anim Sci Inst Livestock, Balochistan 87300, Pakistan; [Ali, Mahboob; Ahmed, Mehtab; Hasni, Muhammad Sajid] Dairy Dev Dept Quetta, Balochistan 87300, Pakistan; [Hameed, Sajid] Islamia Univ Bahawalpur, Univ Coll Vet & Anim Sci, Bahawalpur, Pakistan; [Haq, Inzmam Ul] Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan
推荐引用方式 GB/T 7714	Ali, Mahboob,Avais, Muhammad,Jamal, Muhammad Ameen,et al. Combating multidrug-resistant Staphylococcus aureus isolated from camel milk with extracts of Eucalyptus globulus and Calotropis procera, and their potential role in modulation of resistance to beta-lactam drugs[J],2021,77(10):491-496.
APA	Ali, Mahboob.,Avais, Muhammad.,Jamal, Muhammad Ameen.,Ijaz, Muhammad.,Chaudhry, Mamoona.,...&Haq, Inzmam Ul.(2021).Combating multidrug-resistant Staphylococcus aureus isolated from camel milk with extracts of Eucalyptus globulus and Calotropis procera, and their potential role in modulation of resistance to beta-lactam drugs.MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE,77(10),491-496.
MLA	Ali, Mahboob,et al."Combating multidrug-resistant Staphylococcus aureus isolated from camel milk with extracts of Eucalyptus globulus and Calotropis procera, and their potential role in modulation of resistance to beta-lactam drugs".MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE 77.10(2021):491-496.