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DOI	10.1016/j.livsci.2021.104536
	Molecular marker prediction for days open and pregnancy rate in Holstein cows managed in a warm climate
	Zamorano-Algandar, Ricardo; Sanchez-Castro, Miguel A.; Hernandez-Cordero, Ana, I; Enns, R. Mark; Speidel, Scott E.; Thomas, Milton G.; Medrano, Juan F.; Rincon, Gonzalo; Leyva-Corona, Jose C.; Luna-Nevarez, Guillermo; Reyna-Granados, Javier R.; Luna-Nevarez, Pablo
通讯作者	Luna-Nevarez, P (corresponding author), Inst Tecnol Sonora, Col Ctr, Dept Ciencias Agron & Vet, 5 Febrero 818 Sur, Obregon 85000, Sonora, Mexico.
来源期刊	LIVESTOCK SCIENCE
ISSN	1871-1413
EISSN	1878-0490
出版年	2021
卷号	250
英文摘要	Reproductive management in lactating Holstein cattle is a challenge for dairy producers in Northwestern Mexico where a semi-desert, yet humid, environment is predominant. Under such conditions, a superior cow's ability to get pregnant early during postpartum is desirable to reduce the number of days open and improve fertility parameters. The objective of this study was to predict days open (DO) and pregnancy rate (PR) using molecular markers associated with fertility in lactating Holstein cows managed in a warm climate. This study included 510 cows from three dairy herds located in the Yaqui Valley of Sonora. A blood sample was collected from every cow and spotted onto FTA cards. Each cow was genotyped for 179 tag single nucleotide polymorphisms (SNPs) within 43 genes in the prolactin and GH-IGF1 pathways. An association mixed-effects model identified three SNPs within the genes AVPR1A, PRLR and SSTR2 associated with DO (P < 0.05), and five SNPs within the genes IGFBP2, IGFBP5, PRLR, PIAS1 and SSTR2 associated with PR (P < 0.05). The SNP effects were estimated and used to calculate the individual molecular breeding values (MBV) for DO and PR. Average MBV were 20.91 +/- 0.21 d and 0.29 +/- 0.003% for DO and PR, respectively. The correlation between the MBV and DO was 0.0008 (P = 0.968), whereas correlation between MBV and the estimated breeding value (EBV) for DO was -0.16 (P < 0.001) with an adjusted coefficient of determination (R2) of 2.5%. For PR, its correlation with the MBV was 0.15 (P < 0.001) with a R2 of 2.2%, whereas the correlation between MBV and the EBV for PR was 0.31 (P < 0.001) with a R2 of 9.6%. Heritability estimates were 0.06 +/- 0.11 and 0.04 +/- 0.06 for DO and PR, respectively. In conclusion, candidate gene SNPs from the prolactin and GH-IGF1 pathways were effectively used to construct an MBV for fertility traits in heat-stressed Holstein cattle. These SNPs explained only a small amount of variation for PR, but not for DO; therefore, additional research using denser SNP panels and a larger population is suggested to improve the power of the MBV as genetic predictor for fertility traits in lactating dairy cows managed under warm environmental conditions.
英文关键词	Holstein Days open MBV Pregnancy rate SNP Warm climate
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000687311000006
WOS关键词	FERTILITY TRAITS ; MILK-PRODUCTION ; HEAT-STRESS ; GENETIC MERIT ; IDENTIFICATION ; POLYMORPHISMS ; ASSOCIATION ; HEALTH ; CATTLE
WOS类目	Agriculture, Dairy & Animal Science
WOS研究方向	Agriculture
来源机构	University of California, Davis ; Colorado State University
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364130
作者单位	[Zamorano-Algandar, Ricardo; Leyva-Corona, Jose C.; Luna-Nevarez, Guillermo; Reyna-Granados, Javier R.; Luna-Nevarez, Pablo] Inst Tecnol Sonora, Col Ctr, Dept Ciencias Agron & Vet, 5 Febrero 818 Sur, Obregon 85000, Sonora, Mexico; [Sanchez-Castro, Miguel A.; Hernandez-Cordero, Ana, I; Enns, R. Mark; Speidel, Scott E.; Thomas, Milton G.] Colorado State Univ, Dept Anim Sci, Ft Collins, CO 80523 USA; [Medrano, Juan F.] Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA; [Rincon, Gonzalo] Zoetis Inc, VMRD Genet R&D, Kalamazoo, MI 49007 USA
推荐引用方式 GB/T 7714	Zamorano-Algandar, Ricardo,Sanchez-Castro, Miguel A.,Hernandez-Cordero, Ana, I,et al. Molecular marker prediction for days open and pregnancy rate in Holstein cows managed in a warm climate[J]. University of California, Davis, Colorado State University,2021,250.
APA	Zamorano-Algandar, Ricardo.,Sanchez-Castro, Miguel A..,Hernandez-Cordero, Ana, I.,Enns, R. Mark.,Speidel, Scott E..,...&Luna-Nevarez, Pablo.(2021).Molecular marker prediction for days open and pregnancy rate in Holstein cows managed in a warm climate.LIVESTOCK SCIENCE,250.
MLA	Zamorano-Algandar, Ricardo,et al."Molecular marker prediction for days open and pregnancy rate in Holstein cows managed in a warm climate".LIVESTOCK SCIENCE 250(2021).