干旱区生态环境知识资源中心(Arid): Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis

Arid

DOI	10.1186/s12967-021-03002-1
	Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis
	Zeng, Zihang; Li, Jiali; Zhang, Jianguo; Li, Yangyi; Liu, Xingyu; Chen, Jiarui; Huang, Zhengrong; Wu, Qiuji; Gong, Yan; Xie, Conghua
通讯作者	Xie, CH (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Radiat & Med Oncol, Wuhan, Peoples R China. ; Gong, Y (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Biol Repositories, Wuhan, Peoples R China.
来源期刊	JOURNAL OF TRANSLATIONAL MEDICINE
EISSN	1479-5876
出版年	2021
卷号	19 期号:1
英文摘要	BackgroundTumor microenvironment (TME) is associated with tumor progression and prognosis. Previous studies provided tools to estimate immune and stromal cell infiltration in TME. However, there is still a lack of single index to reflect both immune and stromal status associated with prognosis and immunotherapy responses.MethodsA novel immune and stromal scoring system named ISTMEscore was developed. A total of 15 datasets were used to train and validate this system, containing 2965 samples from lung adenocarcinoma, skin cutaneous melanoma and head and neck squamous cell carcinoma.ResultsThe patients with high immune and low stromal scores (HL) were associated with low ratio of T cell co-inhibitory/stimulatory molecules and low levels of angiogenesis markers, while the patients with low immune and high stromal scores (LH) had the opposite characteristics. The HL patients had immune-centered networks, while the patients with low immune and low stromal scores (LL) had desert-like networks. Moreover, copy number alteration burden was decreased in the HL patients. For the clinical characteristics, our TME classification was an independent prognostic factor. In the 5 cohorts with immunotherapy, the LH patients were linked to the lowest response rate.ConclusionsISTMEscore system could reflect the TME status and predict the prognosis. Compared to previous TME scores, our ISTMEscore was superior in the prediction of prognosis and immunotherapy response.
英文关键词	Tumor microenvironment Multi-task learning Scoring system Prognosis Immunotherapy
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000683729400003
WOS关键词	LUNG ADENOCARCINOMA ; R PACKAGE ; EXPRESSION ; SURVIVAL ; VALIDATION ; PREDICTION ; SIGNATURE ; DISCOVERY ; CARCINOMA ; NIVOLUMAB
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/364058
作者单位	[Zeng, Zihang; Li, Jiali; Zhang, Jianguo; Li, Yangyi; Liu, Xingyu; Chen, Jiarui; Wu, Qiuji; Xie, Conghua] Wuhan Univ, Zhongnan Hosp, Dept Radiat & Med Oncol, Wuhan, Peoples R China; [Huang, Zhengrong; Gong, Yan] Wuhan Univ, Zhongnan Hosp, Dept Biol Repositories, Wuhan, Peoples R China; [Huang, Zhengrong; Gong, Yan] Wuhan Univ, Zhongnan Hosp, Hubei Engn Res Ctr, Tumor Precis Diag & Treatment Technol & Translat, Wuhan, Peoples R China; [Wu, Qiuji; Xie, Conghua] Wuhan Univ, Zhongnan Hosp, Hubei Key Lab Tumor Biol Behav, Wuhan, Peoples R China; [Wu, Qiuji; Xie, Conghua] Wuhan Univ, Zhongnan Hosp, Hubei Canc Clin Study Ctr, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Zihang,Li, Jiali,Zhang, Jianguo,et al. Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis[J],2021,19(1).
APA	Zeng, Zihang.,Li, Jiali.,Zhang, Jianguo.,Li, Yangyi.,Liu, Xingyu.,...&Xie, Conghua.(2021).Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis.JOURNAL OF TRANSLATIONAL MEDICINE,19(1).
MLA	Zeng, Zihang,et al."Immune and stromal scoring system associated with tumor microenvironment and prognosis: a gene-based multi-cancer analysis".JOURNAL OF TRANSLATIONAL MEDICINE 19.1(2021).