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DOI	10.9734/JPRI/2021/v33i42B32422
	Assessment of Hepatoprotective Potential of Manilkara hexandra STEM Bark: An In-vitro Analysis
	Saxena, Prasoon Kumar; Nanda, Deepak; Gupta, Ritu
通讯作者	Saxena, PK (corresponding author), Uttarakhand Tech Univ, Dehra Dun, Uttarakhand, India. ; Saxena, PK (corresponding author), ITS Coll Pharm Ghaziabad, Delhi, India.
来源期刊	JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
ISSN	2456-9119
出版年	2021
卷号	33 期号:42B 页码:19-38
英文摘要	Background: Manilkara hexendra (Bignoniaceae) is tree species, privately known as Rohida, found in Thar Desert districts of northwest and western India. The bark acquired from the stem is utilized as a solution for syphilis, urinary issues, amplification of spleen, gonorrhea, leucoderma, and liver infections. The point of this work is to consider the hepatoprotective impact of unrefined Methanolic removal from the bark portions of Manikara hexendra. The methanolic extricate got from bark portions of Manikara hexendra was assessed via cell line study in HepG2 cell line followed in for hepatoprotective movement in rodents by initiating liver harm via paracetamol and carbon tetrachloride. Results: The methanolic extricate at an oral portion of 200 mg/kg displayed a critical (P < 0.05) defensive impact. These biochemical perceptions were enhanced by histopathological assessment of liver areas. The action might be a consequence of the presence of flavonoid mixes. Moreover, the intense harmfulness of the concentrates gave no indications of poisonousness up to a portion level of 2000 mg/kg. Conclusion: It could be inferred that the methanolic concentrate of Manikara hexendra has huge hepatoprotective properties.
英文关键词	Hepatoprotective Manikara hexendra AST ALT ALP GSH MDA
类型	Article
语种	英语
开放获取类型	gold
收录类别	ESCI
WOS记录号	WOS:000691642400004
WOS关键词	CCL4-INDUCED LIVER-DAMAGE
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363989
作者单位	[Saxena, Prasoon Kumar] Uttarakhand Tech Univ, Dehra Dun, Uttarakhand, India; [Saxena, Prasoon Kumar] ITS Coll Pharm Ghaziabad, Delhi, India; [Nanda, Deepak] Graph Era Univ, Dehra Dun, Uttarakhand, India; [Gupta, Ritu] LLRM Med Coll, Meerut, Uttar Pradesh, India
推荐引用方式 GB/T 7714	Saxena, Prasoon Kumar,Nanda, Deepak,Gupta, Ritu. Assessment of Hepatoprotective Potential of Manilkara hexandra STEM Bark: An In-vitro Analysis[J],2021,33(42B):19-38.
APA	Saxena, Prasoon Kumar,Nanda, Deepak,&Gupta, Ritu.(2021).Assessment of Hepatoprotective Potential of Manilkara hexandra STEM Bark: An In-vitro Analysis.JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL,33(42B),19-38.
MLA	Saxena, Prasoon Kumar,et al."Assessment of Hepatoprotective Potential of Manilkara hexandra STEM Bark: An In-vitro Analysis".JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL 33.42B(2021):19-38.