干旱区生态环境知识资源中心(Arid): Analysis of isothiazolinone preservatives in household deodorizers and air fresheners through solid-phase extraction and liquid chromatography-tandem mass spectrometry

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DOI	10.1080/10826076.2021.1990944
	Analysis of isothiazolinone preservatives in household deodorizers and air fresheners through solid-phase extraction and liquid chromatography-tandem mass spectrometry
	Kawakami, Tsuyoshi; Tahara, Maiko; Ikarashi, Yoshiaki
通讯作者	Kawakami, T (corresponding author), Natl Inst Hlth Sci, Div Environm Chem, Kawasaki Ku, 3-25-26 Tonomachi, Kawasaki, Kanagawa 2109501, Japan.
来源期刊	JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN	1082-6076
EISSN	1520-572X
出版年	2021
英文摘要	Isothiazolinone preservatives are known to cause contact dermatitis. Although they are used in household deodorizers and air fresheners, the actual extent of their use remains unclear. In this study, we developed a method to simultaneously analyze five isothiazolinones (2-methyl-4-isothiazilin-3-one: MI, 5-choro-2-methyl-4-isothiazolin-3-one: CMI, benzisothiazolin-3-one: BIT, 2-n-octyl-4-isothiazolin-3-one: OIT, 4,5-dichloro-n-octyl-4-isothiazolin-3-one: 2Cl-OIT) in spray-type household deodorizers and air fresheners. The samples were analyzed through solid-phase extraction and liquid chromatography-tandem mass spectrometry. Three solid-phase extraction cartridges were examined, and good results were obtained for the OASIS HLB Plus LP cartridge. The recoveries and standard deviations for isothiazolinone preservatives extracted using this cartridge were 72-99 and 1.6-6.0%, respectively. In addition, the limit of detection and limit of quantification were as follow: 0.012 and 0.037 mu g/mL for MI, 0.029 and 0.089 mu g/mL for CMI, 0.032 and 0.098 mu g/mL for BIT, 0.013 and 0.040 mu g/mL for OIT, and 0.015 and 0.047 mu g/mL for 2Cl-OIT. Among the 51 analyzed products, only 10 were detected with isothiazolinone compounds. MI and CMI were detected in five products at concentration levels of 0.31-22 and 0.77-95 mu g/mL, respectively, while BIT was detected in the other five products at 2.7-101 mu g/mL.
英文关键词	Isothiazolinone preservatives household deodorizers air fresheners solid-phase extraction liquid chromatography-tandem mass spectrometry
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000708282100001
WOS关键词	WATER ; METHYLISOTHIAZOLINONE
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363951
作者单位	[Kawakami, Tsuyoshi; Tahara, Maiko; Ikarashi, Yoshiaki] Natl Inst Hlth Sci, Div Environm Chem, Kawasaki, Kanagawa, Japan
推荐引用方式 GB/T 7714	Kawakami, Tsuyoshi,Tahara, Maiko,Ikarashi, Yoshiaki. Analysis of isothiazolinone preservatives in household deodorizers and air fresheners through solid-phase extraction and liquid chromatography-tandem mass spectrometry[J],2021.
APA	Kawakami, Tsuyoshi,Tahara, Maiko,&Ikarashi, Yoshiaki.(2021).Analysis of isothiazolinone preservatives in household deodorizers and air fresheners through solid-phase extraction and liquid chromatography-tandem mass spectrometry.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES.
MLA	Kawakami, Tsuyoshi,et al."Analysis of isothiazolinone preservatives in household deodorizers and air fresheners through solid-phase extraction and liquid chromatography-tandem mass spectrometry".JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES (2021).