干旱区生态环境知识资源中心(Arid): Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk

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DOI	10.2147/JIR.S320096
	Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk
	Burr, Abigail C.; Velazquez, Jalene V.; Ulu, Arzu; Kamath, Rohan; Kim, Sang Yong; Bilg, Amanpreet K.; Najera, Aileen; Sultan, Iman; Botthoff, Jon K.; Aronson, Emma; Nair, Meera G.; Nordgren, Tara M.
通讯作者	Nordgren, TM (corresponding author), Univ Calif Riverside, Div Biomed Sci, 92521 Univ Ave, Riverside, CA 92521 USA.
来源期刊	JOURNAL OF INFLAMMATION RESEARCH
EISSN	1178-7031
出版年	2021
卷号	14 页码:4035-4052
英文摘要	Purpose: The Salton Sea, California's largest lake, is designated as an agricultural drainage reservoir. In recent years, the lake has experienced shrinkage due to reduced water sources, increasing levels of aerosolized dusts in surrounding regions. Communities surrounding the Salton Sea have increased asthma prevalence versus the rest of California; however, a connection between dust inhalation and lung health impacts has not been defined. Methods: We used an established intranasal dust exposure murine model to study the lung inflammatory response following single or repetitive (7-day) exposure to extracts of dusts collected in regions surrounding the Salton Sea (SSDE), complemented with in vitro investigations assessing SSDE impacts on the airway epithelium. Results: In these investigations, single or repetitive SSDE exposure induced significant lung inflammatory cytokine release concomitant with neutrophil influx. Repetitive SSDE exposure led to significant lung eosinophil recruitment and altered expression of genes associated with allergen-mediated immune response, including Clec4e. SSDE treatment of human bronchial epithelial cells (BEAS-2B) induced inflammatory cytokine production at 5-and 24-hours post-treatment. When BEAS-2B were exposed to protease activity-depleted SSDE (PDSSDE) or treated with SSDE in the context of protease-activated receptor-1 and -2 antagonism, inflammatory cytokine release was decreased. Furthermore, repetitive exposure to PDSSDE led to decreased neutrophil and eosinophilic influx and IL-6 release in mice compared to SSDE-challenged mice. Conclusion: These investigations demonstrate potent lung inflammatory responses and tissue remodeling in response to SSDE, in part due to environmental proteases found within the dusts. These studies provide the first evidence supporting a link between environmental dust exposure, protease-mediated immune activation, and respiratory disease in the Salton Sea region.
英文关键词	Salton Sea dust exposure lung inflammation asthma proteases protease-activated receptors
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000687983800002
WOS关键词	SALTON-SEA ; AIRWAY INFLAMMATION ; EPITHELIAL-CELLS ; MITE ALLERGEN ; DESERT DUST ; PROTEASE ; ASTHMA ; ACTIVATION ; POLLUTION ; RECEPTOR
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363943
作者单位	[Burr, Abigail C.; Velazquez, Jalene V.; Ulu, Arzu; Kamath, Rohan; Kim, Sang Yong; Bilg, Amanpreet K.; Najera, Aileen; Sultan, Iman; Nair, Meera G.; Nordgren, Tara M.] Univ Calif Riverside, Div Biomed Sci, 92521 Univ Ave, Riverside, CA 92521 USA; [Botthoff, Jon K.] Univ Calif Riverside, Ctr Conservat Biol, Riverside, CA 92521 USA; [Aronson, Emma] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA
推荐引用方式 GB/T 7714	Burr, Abigail C.,Velazquez, Jalene V.,Ulu, Arzu,et al. Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk[J],2021,14:4035-4052.
APA	Burr, Abigail C..,Velazquez, Jalene V..,Ulu, Arzu.,Kamath, Rohan.,Kim, Sang Yong.,...&Nordgren, Tara M..(2021).Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk.JOURNAL OF INFLAMMATION RESEARCH,14,4035-4052.
MLA	Burr, Abigail C.,et al."Lung Inflammatory Response to Environmental Dust Exposure in Mice Suggests a Link to Regional Respiratory Disease Risk".JOURNAL OF INFLAMMATION RESEARCH 14(2021):4035-4052.