干旱区生态环境知识资源中心(Arid): Polar fraction from Parkinsonia aculeata aerial parts extract improves imbalanced metabolic profile and reduces proinflammatory interleukin levels in white adipose tissue in obese rats induced by western diet

Arid

DOI	10.1016/j.jep.2021.114557
	Polar fraction from Parkinsonia aculeata aerial parts extract improves imbalanced metabolic profile and reduces proinflammatory interleukin levels in white adipose tissue in obese rats induced by western diet
	Franco, Eryvelton S.; Nascimento, Elizabeth; Vasconcelos, Diogo AA.; Silva, Priscila AA.; Novaes, Taciana L.; Feitosa, Maria GS.; Silva, Amanda AM.; Maia, Maria BS.
通讯作者	Nascimento, E (corresponding author), Fed Univ Pernambuco UFPE, Dept Nutr, Dept Nutr, Ctr Hlth Sci, Av Prof Moraes Rego 1235, BR-50670901 Recife, PE, Brazil.
来源期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
EISSN	1872-7573
出版年	2022
卷号	282
英文摘要	Ethnopharmacological relevance: Parkinsonia aculeata L. (Cesalpineaceae) is a medium tree found in the Xingo acute accent region (semi-arid area) in Northeast of Brazil, recognised by local population as an antidiabetic agent. According information from local community, the commonly traditional preparation is prepared as an infusion of the aerial part of the plant and consumed over the day to manage diabetes-related complications. Previous studies have described Parkinsonia aculeate as a product with both hypoglycemic and hypotriglyceridemic effects. Aim of the study: The objective of this study was to evaluate the effects of polar fraction obtained from the hydroethanolic extract of Parkinsonia aculeata (PfrHEPA) on the lipid profile of animals that consumed a westernized diet. Materials and methods: Thirty-six Wistar rats (45-55 g) were fed either with standard control(C) or westernized diet(W) for 120 days. The food intake, body weight evolution and body size were also analyzed. From 120 to 150 days, they were orally treated according to their group with vehicle (distillated water, 10 mL/kg), PfrHEPA at three doses (35, 70 and 140 mg/kg/day) or Gemfibrozil (140 mg/kg/day) for 30 days. Results: The animals fed with westernized diet showed dyslipidemia when compared to animals receiving a standard diet. Treatment with PfrHEPA (140 mg/kg), even with the continued consumption of westernized diet by animals (from 120 to 150 days) promoted a significant reduction in total cholesterol, LDL and triglyceride levels, in relation to untreated W group. PfrHEPA 140 mg/kg reduced the key serum lipids and glycaemia as well as inflammatory cytokines known as important risk factors of cardiovascular diseases. Conclusions: The observed evidence may contribute to the control of metabolic parameters as dyslipidemia corroborating the ethnopharmacological information concerning the antihyperlipidemic and hypoglycemic activities of P. aculeata.
英文关键词	Dyslipidemia Ethnopharmacobotanical Inflammatory cytokines Obesity Rats
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000704891500001
WOS关键词	INSULIN-RESISTANCE ; FAT ; GLYCOSIDES ; LEAVES
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363861
作者单位	[Franco, Eryvelton S.; Silva, Priscila AA.; Novaes, Taciana L.; Feitosa, Maria GS.; Maia, Maria BS.] Fed Univ Pernambuco UFPE, Ctr Biol Sci, Dept Physiol & Pharmacol, BR-50670901 Recife, PE, Brazil; [Silva, Amanda AM.] Univ Pernambuco UPE, Fac Med Sci, Postgrad Program Hlth Sci, Santo Amaro Campus, BR-50010001 Recife, PE, Brazil; [Nascimento, Elizabeth] Fed Univ Pernambuco UFPE, Ctr Hlth Sci, Dept Nutr, BR-50670901 Recife, PE, Brazil
推荐引用方式 GB/T 7714	Franco, Eryvelton S.,Nascimento, Elizabeth,Vasconcelos, Diogo AA.,et al. Polar fraction from Parkinsonia aculeata aerial parts extract improves imbalanced metabolic profile and reduces proinflammatory interleukin levels in white adipose tissue in obese rats induced by western diet[J],2022,282.
APA	Franco, Eryvelton S..,Nascimento, Elizabeth.,Vasconcelos, Diogo AA..,Silva, Priscila AA..,Novaes, Taciana L..,...&Maia, Maria BS..(2022).Polar fraction from Parkinsonia aculeata aerial parts extract improves imbalanced metabolic profile and reduces proinflammatory interleukin levels in white adipose tissue in obese rats induced by western diet.JOURNAL OF ETHNOPHARMACOLOGY,282.
MLA	Franco, Eryvelton S.,et al."Polar fraction from Parkinsonia aculeata aerial parts extract improves imbalanced metabolic profile and reduces proinflammatory interleukin levels in white adipose tissue in obese rats induced by western diet".JOURNAL OF ETHNOPHARMACOLOGY 282(2022).