干旱区生态环境知识资源中心(Arid): Chemical diversity analysis and biological activities evaluation of different polyphenolic extracts of Marrubium deserti De Noe from Algeria

Arid

DOI	10.1016/j.jep.2021.114494
	Chemical diversity analysis and biological activities evaluation of different polyphenolic extracts of Marrubium deserti De Noe from Algeria
	Saad, Somia; Ouafi, Saida; Meguellati, Hassina; Djemouai, Nadjette
通讯作者	Saad, S (corresponding author), Ctr Rech Sci & Tech Reg Aride CRSTRA, Biskra, Algeria.
来源期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
EISSN	1872-7573
出版年	2021
卷号	281
英文摘要	Ethnopharmacological relevance: Marrubium deserti De Noe acute accent (Lamiaceae) commonly known as desert horehound, is a small perennial herb distributed in arid climates. This plant has been used in Algeria for the treatment of cold, cough, fever and inflammation. Aim of the study: This study aimed to perform a phytochemical analysis and to evaluate the effect of diethyl ether (ExDiEth), n-butanol (ExBut) and hydroalcoholic (ExHyD) extracts of the aerial parts of M. deserti De Noe acute accent on inflammation, nociceptive response and fever in animal models. Materials and methods: The total phenolic content and the different phenolic fraction (flavones-flavonols, free aglycones, anthocyanidins, C-glycosides and flavonic heterosides) were quantified in order to study the chemical diversity. The anti-inflammatory effect was evaluated using carrageenan-induced paw oedema test and the nociceptive response was determined by the chemical method using acetic acid-induced writhing response and formalin-induced paw licking tests and by the thermal method using the hot plate in mice. In addition, anti-fever was investigated using yeast-induced pyrexia in rats. Results: Quantitative analysis revealed that among all extracts, ExBut had a higher phenolic content and the aerial parts of M. deserti De Noe acute accent collected from two different sites (Biskra and Tamanresset) had a significant difference in the contents of flavonic heterosids and flavones-flavonols. PCA and CA showed a strong intraspecific variability of M. deserti De Noe acute accent individuals. Our results showed that the ExDiEth, ExBut and ExHyD treatments prevented the increase of paw oedema by 56.25%, 66.65% and 45.56% inhibition percent, respectively. Moreover, treatments with these extracts significantly (p<0.05) decreased the number of writhing and increased the reaction time to thermal stimulation as well as demonstrated reduction in paw licking time both at early and late phases. Likewise, they also showed a significant reduction of yeast-induced pyrexia till 4 h of treatment. Conclusion: Results from this study show that M. deserti De Noe acute accent aerial parts exhibited anti-inflammatory, analgesic with central and peripheral actions and antipyretic activities which could be associated with the presence of some phytochemicals as flavones, flavonols, flavonic heterosids and phenolic acids.
英文关键词	M deserti Multivariate analysis Polyphenols Inflammation Pain Fever
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000704860400008
WOS关键词	PHENOLIC-COMPOUNDS ; ANTIOXIDANT ACTIVITY ; ANTIINFLAMMATORY ACTIVITIES ; ANTIMICROBIAL ACTIVITIES ; AQUEOUS EXTRACT ; LEAF EXTRACTS ; ESSENTIAL OIL ; AERIAL PARTS ; PLANTS ; INFLAMMATION
WOS类目	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363860
作者单位	[Saad, Somia] Ctr Rech Sci & Tech Reg Aride CRSTRA, Biskra, Algeria; [Saad, Somia; Ouafi, Saida; Meguellati, Hassina; Djemouai, Nadjette] Univ Sci & Technol Houari Boumed USTHB, Lab Rech Zones Arides LRZA, BP32 El Alia, Bab Ezzouar 16111, Alger, Algeria; [Djemouai, Nadjette] Univ Ghardaia, Fac Sci Nat & Vie & Sci Terre, Dept Biol, BP 455, Ghardaia 47000, Algeria; [Djemouai, Nadjette] Ecole Normale Super Kouba, Lab Biol Syst Microbiens LBSM, BP 92, Kouba 16050, Alger, Algeria
推荐引用方式 GB/T 7714	Saad, Somia,Ouafi, Saida,Meguellati, Hassina,et al. Chemical diversity analysis and biological activities evaluation of different polyphenolic extracts of Marrubium deserti De Noe from Algeria[J],2021,281.
APA	Saad, Somia,Ouafi, Saida,Meguellati, Hassina,&Djemouai, Nadjette.(2021).Chemical diversity analysis and biological activities evaluation of different polyphenolic extracts of Marrubium deserti De Noe from Algeria.JOURNAL OF ETHNOPHARMACOLOGY,281.
MLA	Saad, Somia,et al."Chemical diversity analysis and biological activities evaluation of different polyphenolic extracts of Marrubium deserti De Noe from Algeria".JOURNAL OF ETHNOPHARMACOLOGY 281(2021).