干旱区生态环境知识资源中心(Arid): Pyridostigmine bromide, chlorpyrifos, and DEET combined Gulf War exposure insult depresses mitochondrial function in neuroblastoma cells

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DOI	10.1002/jbt.22913
	Pyridostigmine bromide, chlorpyrifos, and DEET combined Gulf War exposure insult depresses mitochondrial function in neuroblastoma cells
	Delic, Vedad; Karp, Joshua; Klein, Julian; Stalnaker, Katherine J.; Murray, Kathleen E.; Ratliff, Whitney A.; Myers, Catherine E.; Beck, Kevin D.; Citron, Bruce A.
通讯作者	Delic, V (corresponding author), Res & Dev, VA New Jersey Hlth Care Syst, Lab Mol Biol, Bldg 16,Room 16-130,385 Tremont Ave, East Orange, NJ 07018 USA.
来源期刊	JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
ISSN	1095-6670
EISSN	1099-0461
出版年	2021
英文摘要	Gulf War Illness (GWI) is defined by the Centers for Disease Control and Prevention (CDC) as a multi-symptom illness having at least one symptom from two of three factors, which include: fatigue, mood-cognition problems, and musculoskeletal disorders. The cluster of long-term symptoms is unique to military personnel from coalition countries including United States, Australia, and the United Kingdom that served in Operation Desert Storm from 1990 to 1991. Reporting of these symptoms is much lower among soldiers deployed in other parts of the world like Bosnia during the same time period. The exact cause of GWI is unknown, but combined exposure to N,N-diethyl-m-toluamide (DEET), organophosphates like chlorpyrifos (CPF), and pyridostigmine bromide (PB), has been hypothesized as a potential mechanism. Mitochondrial dysfunction is known to occur in most neurodegenerative diseases that share symptoms with GWI and has therefore been implicated in GWI. Although exposure to these and other toxicants continues to be investigated as potential causes of GWI, their combined impact on mitochondrial physiology remains unknown. In this study, the effects of combined GWI toxicant exposure on mitochondrial function were determined in a commonly used and readily available immortalized cell line (N2a), whose higher rate of oxygen consumption resembles that of highly metabolic neurons in vivo. We report that combined exposure containing pesticide CPF 71 mu M, insect repellants DEET 78 mu M, and antitoxins PB 19 mu M, causes profound mitochondrial dysfunction after a 4-h incubation resulting in decreased mitochondrial respiratory states in the absence of proapoptotic signaling, proton leak, or significant increase in reactive oxygen species production.
英文关键词	ATP Gulf War Illness mitochondria oxygen consumption reactive oxygen species
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000696142500001
WOS关键词	MULTISYMPTOM ILLNESS ; ALZHEIMERS-DISEASE ; HEALTH ; N,N-DIETHYL-M-TOLUAMIDE ; PERMETHRIN ; COMBINATION ; PATHWAYS ; DEMENTIA ; VETERANS ; LIPIDS
WOS类目	Biochemistry & Molecular Biology ; Toxicology
WOS研究方向	Biochemistry & Molecular Biology ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363795
作者单位	[Delic, Vedad; Karp, Joshua; Klein, Julian; Stalnaker, Katherine J.; Murray, Kathleen E.; Citron, Bruce A.] VA New Jersey Hlth Care Syst Res & Dev, Lab Mol Biol, Mailstop 15, East Orange, NJ USA; [Delic, Vedad; Myers, Catherine E.; Beck, Kevin D.; Citron, Bruce A.] Rutgers New Jersey Med Sch, Dept Pharmacol Physiol & Neurosci, Newark, NJ USA; [Karp, Joshua; Klein, Julian; Murray, Kathleen E.] Rutgers Sch Grad Studies, Newark, NJ USA; [Stalnaker, Katherine J.; Myers, Catherine E.; Beck, Kevin D.] VA New Jersey Hlth Care Syst Res & Dev, NeuroBehav Res Lab, Mailstop 15, East Orange, NJ USA; [Ratliff, Whitney A.] Bay Pines VA Healthcare Syst Res & Dev, Lab Mol Biol Bay Pines VA Healthcare Syst Res & D, Bay Pines, FL USA
推荐引用方式 GB/T 7714	Delic, Vedad,Karp, Joshua,Klein, Julian,et al. Pyridostigmine bromide, chlorpyrifos, and DEET combined Gulf War exposure insult depresses mitochondrial function in neuroblastoma cells[J],2021.
APA	Delic, Vedad.,Karp, Joshua.,Klein, Julian.,Stalnaker, Katherine J..,Murray, Kathleen E..,...&Citron, Bruce A..(2021).Pyridostigmine bromide, chlorpyrifos, and DEET combined Gulf War exposure insult depresses mitochondrial function in neuroblastoma cells.JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY.
MLA	Delic, Vedad,et al."Pyridostigmine bromide, chlorpyrifos, and DEET combined Gulf War exposure insult depresses mitochondrial function in neuroblastoma cells".JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021).