干旱区生态环境知识资源中心(Arid): Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey

Arid

DOI	10.26650/IstanbulJPharm.2020.0064
	Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey
	Akyuz, Mehmet; Karagoz, Isik Didem; Inci, Sule; Kilic, Ibrahim Halil; Kirbag, Sevda; Simitcioglu, Basak
通讯作者	Akyuz, M (corresponding author), Bitlis Eren Univ, Sci & Arts Fac, Dept Biol, Bitlis, Turkey.
来源期刊	ISTANBUL JOURNAL OF PHARMACY
EISSN	2587-2087
出版年	2021
卷号	51 期号:2 页码:198-203
英文摘要	Background and Alms: This study aims to investigate the cytotoxicity and DNA protective effects of semi-arid, arid, or desert truffles such as the Terfezia and Picoa species. Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV and H2O2. The cytotoxic effects of waterand methanol extracts of the Terfezia and Picoa species on H1299 and HUVEC cells were evaluated using the MTT assay. Results: Higher concentrations of T. otbiensis and P. lefebvrei extracts have demonstrated a DNA protective effect. The water extract of P. juniperi only at a 40 mg/mL concentration demonstrated a DNA-protective effect, whereas T. boudieri extract did not show any DNA-protective effect at all concentrations tested. H1299 cells showed more sensitivity to the water extract of T. otbiensis (4.66%), P. juniperi (12.04%), P. lefebvrei (21.93%), and the methanol extract of T. boudieri (20.93%). In general, the water and methanol extracts of the Terfezia and Picoa species demonstrated the least cytotoxic effects on HUVEC cells, except for the water extract of P. juniperi (38.46%). Conclusions: In conclusion, results obtained from this study show that the Terfezia and Picoa truffle species have potential DNA protective and cancer prevention properties.
英文关键词	arid-semi arid truffle DNA protective activity cytotoxicity effect mushroom Terfezia Picoa
类型	Article
语种	英语
开放获取类型	Green Submitted, gold
收录类别	ESCI
WOS记录号	WOS:000691608500006
WOS关键词	IN-VITRO ANTIOXIDANT ; DAMAGE PROTECTION ; CHEMICAL-COMPOSITION ; TRUFFLE TERFEZIA ; PLEUROTUS SPP. ; MUSHROOMS ; CANCER ; EXTRACTS ; STATISTICS ; ANTICANCER
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363695
作者单位	[Akyuz, Mehmet] Bitlis Eren Univ, Sci & Arts Fac, Dept Biol, Bitlis, Turkey; [Karagoz, Isik Didem; Kilic, Ibrahim Halil; Simitcioglu, Basak] Gaziantep Univ, Sci & Arts Fac, Dept Biol, Gaziantep, Turkey; [Inci, Sule; Kirbag, Sevda] Firat Univ, Sci Fac, Dept Biol, Elazig, Turkey
推荐引用方式 GB/T 7714	Akyuz, Mehmet,Karagoz, Isik Didem,Inci, Sule,et al. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey[J],2021,51(2):198-203.
APA	Akyuz, Mehmet,Karagoz, Isik Didem,Inci, Sule,Kilic, Ibrahim Halil,Kirbag, Sevda,&Simitcioglu, Basak.(2021).Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey.ISTANBUL JOURNAL OF PHARMACY,51(2),198-203.
MLA	Akyuz, Mehmet,et al."Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey".ISTANBUL JOURNAL OF PHARMACY 51.2(2021):198-203.