干旱区生态环境知识资源中心(Arid): The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model

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DOI	10.1163/22238980-bja10035
	The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model
	Telerman, Alona; Kashman, Yoel; Ofir, Rivka; Elmann, Anat
通讯作者	Elmann, A (corresponding author), Agr Res Org, Dept Food Sci, Volcani Ctr, IL-7505101 Rishon Leziyyon, Israel.
来源期刊	ISRAEL JOURNAL OF PLANT SCIENCES
ISSN	0792-9978
EISSN	2223-8980
出版年	2021
卷号	68 期号:1-2 页码:107-114
英文摘要	Plant-derived substances have been shown to affect potential targets in inflammatory diseases. We have previously purified from the desert plant Achillea fragrantissima, a sesquiterpene lactone named achillolide A, and demonstrated its anti-inflammatory activities in cultured brain macrophages named microglial cells. In the present study, we further investigated achillolide A in alleviating atopic dermatitis, a chronic and recurring inflammatory skin disease. We investigated achillolide A for its in vivo anti-inflammatory activity using the oxazolone model of atopic dermatitis in mice, in which oxazolone induces ear swelling. Our results show that mice treated with achillolide A showed a significant decrease in the oxazolone-induced ear swelling. Since macrophages are inflammatory cells that play a pivotal role in the pathogenesis of atopic dermatitis, the anti-inflammatory effects of achillolide A were also studied in spleen cells. We demonstrated that achillolide A reduced the levels of LPS-induced inflammatory cytokines IL-2, IL-6, TNF alpha, IFN gamma and IL-12 that were secreted from cultured splenocytes. These data suggest that achillolide A should be considered for further research in treating atopic dermatitis.
英文关键词	Achillolide A Achillea fragrantissima sesquiterpene-lactones splenocytes inflammation phytochemicals atopic dermatitis
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000703604100002
WOS关键词	NF-KAPPA-B ; MEDICINAL-PLANTS ; IN-VITRO ; INHIBITION ; ANTICANCER ; ACTIVATION ; VIVO ; MICE
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363693
作者单位	[Telerman, Alona; Elmann, Anat] Agr Res Org, Dept Food Sci, Volcani Ctr, IL-7505101 Rishon Leziyyon, Israel; [Kashman, Yoel] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Chem, IL-69978 Tel Aviv, Israel; [Ofir, Rivka] Dead Sea & Arava Sci Ctr, Cent Arava Branch, IL-8682500 Merkaz Sapir, Israel
推荐引用方式 GB/T 7714	Telerman, Alona,Kashman, Yoel,Ofir, Rivka,et al. The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model[J],2021,68(1-2):107-114.
APA	Telerman, Alona,Kashman, Yoel,Ofir, Rivka,&Elmann, Anat.(2021).The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model.ISRAEL JOURNAL OF PLANT SCIENCES,68(1-2),107-114.
MLA	Telerman, Alona,et al."The natural anti-inflammatory sesquiterpene lactone achillolide A reduces atopic dermatitis in a murine model".ISRAEL JOURNAL OF PLANT SCIENCES 68.1-2(2021):107-114.