干旱区生态环境知识资源中心(Arid): The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China

Arid

DOI	10.2147/COPD.S321150
	The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China
	Abudureheman, Zulipikaer; Li, Li; Zhong, XueMei; Xu, JingRan; Gong, Hui; Yilamujiang, Subinuer; Ren, Jie; Xie, ChengXin; Zheng, AiFang; Tuerxun, Dilala; Abudukadeer, Ayiguzali; Aini, Paierda; Xu, AiMin; Zou, XiaoGuang
通讯作者	Zou, XG (corresponding author), First Peoples Hosp Kashi, Dept Resp & Crit Care Med, Kashi, Peoples R China. ; Xu, AM (corresponding author), First Peoples Hosp Kashi, Dept Clin Lab, Kashi, Peoples R China.
来源期刊	INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
ISSN	1178-2005
出版年	2021
卷号	16 页码:2631-2636
英文摘要	Background: Kashi city is situated near the Taklamakan desert and has a high incidence rate of chronic obstructive pulmonary disease (COPD). In this study, we aimed to explore the relationship between the SNP of the SREK1 gene locus rs74794265 and the susceptibility to COPD among the Uyghur population in Kashi, XinJiang, China. Methods: A total of 541 patients with COPD and 534 control subjects were included in this study. Sanger sequencing was used to analyze the SNP of the SREK1 gene locus rs74794265 site. The distribution of genotypes in different genetic models between the case and control group were analyzed by logistic regression analysis after adjusting for age, sex, and smoking history. Results: The SREK1 gene SNP locus rs74794265 included two genotypes, namely, C/C and C/ T, of which C/C was the wildtype; The risk of COPD was significantly lower in patients with heterozygous C/T in rs74794265 [p=0.0236, OR=0.3677 (0.1547-0.8742)], and the allele fre-quency of T was also significantly lower in the patient group [p=0.0245, OR=0.3728 (0.1577- 0.8811)]. The heterozygous C/T of rs74794265 among non-smoking COPD patients was sig-nificantly lower than other COPD patients [p=0.0298, OR=0.3217 (0.1156-0.8949)], and there was no significant correlation of the heterozygous C/T genotype in smokers. Conclusion: We found that the rs74794265 heterozygous C/T genotype significantly reduces the risk of COPD. The C/T genotype is likely a protective factor for COPD in the Kashi region. We speculate that the occurrence of COPD in this area is probably more related to desert climate condition and genetic factors than smoking status.
英文关键词	COPD SREK1 gene polymorphism rs74794265 locus Uyghur population
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000703451000001
WOS关键词	OBSTRUCTIVE PULMONARY-DISEASE
WOS类目	Respiratory System
WOS研究方向	Respiratory System
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363622
作者单位	[Abudureheman, Zulipikaer; Gong, Hui; Yilamujiang, Subinuer] First Peoples Hosp Kashi, Dept Clin Res, Ctr Infect Dis Pulm TB, Kashi, Peoples R China; [Li, Li; Zhong, XueMei; Xu, JingRan; Ren, Jie; Xie, ChengXin; Zheng, AiFang; Tuerxun, Dilala; Abudukadeer, Ayiguzali; Aini, Paierda; Zou, XiaoGuang] First Peoples Hosp Kashi, Dept Resp & Crit Care Med, Kashi, Peoples R China; [Xu, AiMin] First Peoples Hosp Kashi, Dept Clin Lab, Kashi, Peoples R China
推荐引用方式 GB/T 7714	Abudureheman, Zulipikaer,Li, Li,Zhong, XueMei,et al. The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China[J],2021,16:2631-2636.
APA	Abudureheman, Zulipikaer.,Li, Li.,Zhong, XueMei.,Xu, JingRan.,Gong, Hui.,...&Zou, XiaoGuang.(2021).The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China.INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE,16,2631-2636.
MLA	Abudureheman, Zulipikaer,et al."The rs74794265 SNP of the SREK1 Gene is Associated with COPD in Kashi, China".INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 16(2021):2631-2636.