干旱区生态环境知识资源中心(Arid): Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep

Arid

DOI	10.3390/genes12081243
	Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep
	Abousoliman, Ibrahim; Reyer, Henry; Oster, Michael; Murani, Eduard; Mohamed, Ismail; Wimmers, Klaus
通讯作者	Wimmers, K (corresponding author), Leibniz Inst Farm Anim Biol, Wilhelm Stahl Allee 2, D-18196 Dummerstorf, Germany. ; Wimmers, K (corresponding author), Univ Rostock, Fac Agr & Environm Sci, Justus von Liebig Weg 7, D-18059 Rostock, Germany.
来源期刊	GENES
EISSN	2073-4425
出版年	2021
卷号	12 期号:8
英文摘要	Sheep play a critical role in the agricultural and livestock sector in Egypt. For sheep meat production, growth traits such as birth and weaning weights are very important and determine the supply and income of local farmers. The Barki sheep originates from the northeastern coastal zone of Africa, and due to its good adaptation to the harsh environmental conditions, it contributes significantly to the meat production in these semi-arid regions. This study aimed to use a genome-wide SNP panel to identify genomic regions that are diversified between groups of individuals of Egyptian Barki sheep with high and low growth performance traits. In this context, from a phenotyped population of 140 lambs of Barki sheep, 69 lambs were considered for a genome-wide scan with the Illumina OvineSNP50 V2 BeadChip. The selected lambs were grouped into divergent subsets with significantly different performance for birth weight and weaning weight. After quality control, 63 animals and 40,383 SNPs were used for analysis. The fixation index (F-ST) for each SNP was calculated between the groups. The results verified genomic regions harboring some previously proposed candidate genes for traits related to body growth, i.e., EYA2, GDF2, GDF10, MEF2B, SLC16A7, TBX15, TFAP2B, and TNNC2. Moreover, novel candidate genes were proposed with known functional implications on growth processes such as CPXM2 and LRIG3. Subsequent association analysis showed significant effects of the considered SNPs on birth and weaning weights. Results highlight the genetic diversity associated with performance traits and thus the potential to improve growth traits in the Barki sheep breed.
英文关键词	Barki sheep growth birth weight weaning weight indigenous sheep lamb SNP chip
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000689120900001
WOS关键词	T-BOX GENES ; MOLECULAR CHARACTERIZATION ; TRANSCRIPTION FACTOR ; TROPONIN COMPLEX ; EXPRESSION ; ASSOCIATION ; PERFORMANCE ; PARAMETERS ; MUSCLE ; SIGNATURES
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363370
作者单位	[Abousoliman, Ibrahim; Reyer, Henry; Oster, Michael; Murani, Eduard; Wimmers, Klaus] Leibniz Inst Farm Anim Biol, Wilhelm Stahl Allee 2, D-18196 Dummerstorf, Germany; [Abousoliman, Ibrahim; Mohamed, Ismail] Desert Res Ctr, Dept Anim & Poultry Breeding, 1 Mathaf El Matareya St, Cairo 11753, Egypt; [Wimmers, Klaus] Univ Rostock, Fac Agr & Environm Sci, Justus von Liebig Weg 7, D-18059 Rostock, Germany
推荐引用方式 GB/T 7714	Abousoliman, Ibrahim,Reyer, Henry,Oster, Michael,et al. Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep[J],2021,12(8).
APA	Abousoliman, Ibrahim,Reyer, Henry,Oster, Michael,Murani, Eduard,Mohamed, Ismail,&Wimmers, Klaus.(2021).Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep.GENES,12(8).
MLA	Abousoliman, Ibrahim,et al."Genome-Wide Analysis for Early Growth-Related Traits of the Locally Adapted Egyptian Barki Sheep".GENES 12.8(2021).