干旱区生态环境知识资源中心(Arid): Leismanicidal Activity of Propolis Collected in the Semiarid Region of Brazil

Arid

DOI	10.3389/fphar.2021.702032
	Leismanicidal Activity of Propolis Collected in the Semiarid Region of Brazil
	Cavalcante, Giani Maria; Camara, Celso Amorim; Sarmento Da Silva, Eva Monica; Santos, Mariana Silva; Leite, Anderson Brandao; Queiroz, Aline Cavalcanti; Da Silva, Amanda Evelyn; Araujo, Morgana Vital; Alexandre-Moreira, Magna Suzana; Sarmento Silva, Tania Maria
通讯作者	Silva, TMS (corresponding author), Rural Fed Univ Pernambuco, Chem Dept, Phytochem Bioprospecting Lab, Pernambuco, Brazil.
来源期刊	FRONTIERS IN PHARMACOLOGY
EISSN	1663-9812
出版年	2021
卷号	12
英文摘要	Objective: The aim of the current study is to investigate the chemical composition, cytotoxic effect, and leishmanicidal activity of propolis collected in the semi-arid region of Bahia, Brazil. Methods: EtOH extract, hexane, EtOAc and MeOH fractions from propolis were analyzed by ultra-performance liquid chromatography coupled with diode array detector and quadrupole time-of-flight mass spectrometry. The identification was based on the exact mass, general fragmentation behaviors and UV absorption of the flavonoids. The in vitro cytotoxic effect and leishmanicidal activity of ethanolic extract, hexane, ethyl acetate, and methanolic fractions of propolis were evaluated. Results: Five triterpenes and twenty-four flavonoids were identified. The propolis did not present toxicity to the host cell up to the maximum concentration tested. In addition, all tested samples showed statistically significant activity against promastigotes of Leishmania chagasi and Leishmania amazonensis. Regarding the activity against amastigote forms of L. amazonensis, the hexane fraction, presented statistically significant activity with IC50 of 1.3 +/- 0.1 mu g/ml. Conclusion: The results support the idea that propolis can be used for future antileishmania studies.
英文关键词	flavonoids propolis leishmanicidal activity Leishmania (Leishmania) amazonensis Leishmania (Leishmania) chagasi
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000673620700001
WOS关键词	RADICAL SCAVENGING ACTIVITY ; CHEMICAL-COMPOSITION ; ANTIOXIDANT ACTIVITY ; PHENOLIC-COMPOUNDS ; MASS-SPECTROMETRY ; IN-VITRO ; POLLEN ; ANTIBACTERIAL ; APIDAE ; BAHIA
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363333
作者单位	[Cavalcante, Giani Maria; Camara, Celso Amorim; Sarmento Silva, Tania Maria] Rural Fed Univ Pernambuco, Chem Dept, Phytochem Bioprospecting Lab, Pernambuco, Brazil; [Sarmento Da Silva, Eva Monica] Fed Univ Sao Francisco Valley, Zootech Coll, Pernambuco, Brazil; [Santos, Mariana Silva; Leite, Anderson Brandao; Queiroz, Aline Cavalcanti; Da Silva, Amanda Evelyn; Araujo, Morgana Vital; Alexandre-Moreira, Magna Suzana] Univ Fed Alagoas, Inst Biol & Hlth Sci, Pharmacol & Immun Lab, Maceio, Alagoas, Brazil; [Queiroz, Aline Cavalcanti] Univ Fed Alagoas, Microbiol Immunol & Parasitol Lab, Campus Arapiraca, Maceio, Alagoas, Brazil
推荐引用方式 GB/T 7714	Cavalcante, Giani Maria,Camara, Celso Amorim,Sarmento Da Silva, Eva Monica,et al. Leismanicidal Activity of Propolis Collected in the Semiarid Region of Brazil[J],2021,12.
APA	Cavalcante, Giani Maria.,Camara, Celso Amorim.,Sarmento Da Silva, Eva Monica.,Santos, Mariana Silva.,Leite, Anderson Brandao.,...&Sarmento Silva, Tania Maria.(2021).Leismanicidal Activity of Propolis Collected in the Semiarid Region of Brazil.FRONTIERS IN PHARMACOLOGY,12.
MLA	Cavalcante, Giani Maria,et al."Leismanicidal Activity of Propolis Collected in the Semiarid Region of Brazil".FRONTIERS IN PHARMACOLOGY 12(2021).