干旱区生态环境知识资源中心(Arid): Altered Homotopic Functional Connectivity Within White Matter in the Early Stages of Alzheimer's Disease

Arid

DOI	10.3389/fnins.2021.697493
	Altered Homotopic Functional Connectivity Within White Matter in the Early Stages of Alzheimer's Disease
	Wang, Pan; Wang, Zedong; Wang, Jianlin; Jiang, Yuan; Zhang, Hong; Li, Hongyi; Biswal, Bharat B.
通讯作者	Biswal, BB (corresponding author), Univ Elect Sci & Technol China, Chengdu Brain Sci Inst, Clin Hosp,Minist Educ MOE, Sch Life Sci & Technol,Ctr Informat Med,Key Lab N, Chengdu, Peoples R China. ; Li, HY (corresponding author), Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China. ; Biswal, BB (corresponding author), New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA.
来源期刊	FRONTIERS IN NEUROSCIENCE
EISSN	1662-453X
出版年	2021
卷号	15
英文摘要	Alzheimer's disease (AD) is a progressive neurodegenerative disorder with memory loss and cognitive impairment. The white matter (WM) BOLD signal has recently been shown to provide an important role in understanding the intrinsic cerebral activity. Although the altered homotopic functional connectivity within gray matter (GM-HFC) has been examined in AD, the abnormal HFC to WM remains unknown. The present study sought to identify changes in the WM-HFC and anatomic characteristics by combining functional magnetic resonance imaging with diffusion tensor imaging (DTI). Resting-state and DTI magnetic resonance images were collected from the OASIS-3 dataset and consisted of 53 mild cognitive impairment (MCI) patients, 90 very MCI (VMCI), and 100 normal cognitive (NC) subjects. Voxel-mirrored HFC was adopted to examine whether WM-HFC was disrupted in VMCI and MCI participants. Moreover, the DTI technique was used to investigate whether specific alterations of WM-HFC were associated with anatomic characteristics. Support vector machine analyses were used to identify the MCI and VMCI participants using the abnormal WM-HFC as the features. Compared with NC, MCI, and VMCI participants showed significantly decreased GM-HFC in the middle occipital gyrus and inferior parietal gyrus and decreased WM-HFC in the bilateral middle occipital and parietal lobe-WM. In addition, specific WM-functional network alteration for the bilateral sub-lobar-WM was found in MCI subjects. MCI subjects showed abnormal anatomic characteristics for bilateral sub-lobar and parietal lobe-WM. Results of GM-HFC mainly showed common neuroimaging features for VMCI and MCI subjects, whereas analysis of WM-HFC showed specific clinical neuromarkers and effectively compensated for the lack of GM-HFC to distinguish NC, VMCI, and MCI subjects.
英文关键词	Alzheimer's disease DTI homotopic functional connectivity mild cognitive impairment support vector machine
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000704483600001
WOS关键词	MILD COGNITIVE IMPAIRMENT ; BRAIN ACTIVITY ; GRAY-MATTER ; STATE ; CORTEX ; NETWORKS ; DEMENTIA ; SINGLE
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363330
作者单位	[Wang, Pan; Wang, Zedong; Wang, Jianlin; Jiang, Yuan; Zhang, Hong; Biswal, Bharat B.] Univ Elect Sci & Technol China, Chengdu Brain Sci Inst, Clin Hosp,Minist Educ MOE, Sch Life Sci & Technol,Ctr Informat Med,Key Lab N, Chengdu, Peoples R China; [Li, Hongyi] Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China; [Biswal, Bharat B.] New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA
推荐引用方式 GB/T 7714	Wang, Pan,Wang, Zedong,Wang, Jianlin,et al. Altered Homotopic Functional Connectivity Within White Matter in the Early Stages of Alzheimer's Disease[J],2021,15.
APA	Wang, Pan.,Wang, Zedong.,Wang, Jianlin.,Jiang, Yuan.,Zhang, Hong.,...&Biswal, Bharat B..(2021).Altered Homotopic Functional Connectivity Within White Matter in the Early Stages of Alzheimer's Disease.FRONTIERS IN NEUROSCIENCE,15.
MLA	Wang, Pan,et al."Altered Homotopic Functional Connectivity Within White Matter in the Early Stages of Alzheimer's Disease".FRONTIERS IN NEUROSCIENCE 15(2021).