干旱区生态环境知识资源中心(Arid): Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases

Arid

DOI	10.3389/fnins.2021.736888
	Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases
	Ki, Soo Mi; Jeong, Hui Su; Lee, Ji Eun
通讯作者	Lee, JE (corresponding author), Sungkyunkwan Univ, Dept Hlth Sci & Technol, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea. ; Lee, JE (corresponding author), Samsung Biomed Res Inst, Samsung Med Ctr, Seoul, South Korea.
来源期刊	FRONTIERS IN NEUROSCIENCE
EISSN	1662-453X
出版年	2021
卷号	15
英文摘要	Many neurodegenerative diseases have been associated with defects in primary cilia, which are cellular organelles involved in diverse cellular processes and homeostasis. Several types of glial cells in both the central and peripheral nervous systems not only support the development and function of neurons but also play significant roles in the mechanisms of neurological disease. Nevertheless, most studies have focused on investigating the role of primary cilia in neurons. Accordingly, the interest of recent studies has expanded to elucidate the role of primary cilia in glial cells. Correspondingly, several reports have added to the growing evidence that most glial cells have primary cilia and that impairment of cilia leads to neurodegenerative diseases. In this review, we aimed to understand the regulatory mechanisms of cilia formation and the disease-related functions of cilia, which are common or specific to each glial cell. Moreover, we have paid close attention to the signal transduction and pathological mechanisms mediated by glia cilia in representative neurodegenerative diseases. Finally, we expect that this field of research will clarify the mechanisms involved in the formation and function of glial cilia to provide novel insights and ideas for the treatment of neurodegenerative diseases in the future.
英文关键词	glia primary cilia myelination nerve regeneration neurological disease
类型	Review
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000708946100001
WOS关键词	NF-KAPPA-B ; AMYOTROPHIC-LATERAL-SCLEROSIS ; REPEAT KINASE 2 ; PROMOTES PRIMARY CILIOGENESIS ; SCHWANN-CELLS ; SONIC HEDGEHOG ; PARKINSONS-DISEASE ; NERVOUS-SYSTEM ; ADENYLYL-CYCLASE ; PSA-NCAM
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363329
作者单位	[Ki, Soo Mi; Jeong, Hui Su; Lee, Ji Eun] Sungkyunkwan Univ, Dept Hlth Sci & Technol, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea; [Lee, Ji Eun] Samsung Biomed Res Inst, Samsung Med Ctr, Seoul, South Korea
推荐引用方式 GB/T 7714	Ki, Soo Mi,Jeong, Hui Su,Lee, Ji Eun. Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases[J],2021,15.
APA	Ki, Soo Mi,Jeong, Hui Su,&Lee, Ji Eun.(2021).Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases.FRONTIERS IN NEUROSCIENCE,15.
MLA	Ki, Soo Mi,et al."Primary Cilia in Glial Cells: An Oasis in the Journey to Overcoming Neurodegenerative Diseases".FRONTIERS IN NEUROSCIENCE 15(2021).