干旱区生态环境知识资源中心(Arid): Prognostic Effect of Microenvironment Phenotype in Triple-Negative Breast Cancer: Biomarker Analysis of a Prospective Trial

Arid

DOI	10.3389/fmolb.2021.752154
	Prognostic Effect of Microenvironment Phenotype in Triple-Negative Breast Cancer: Biomarker Analysis of a Prospective Trial
	Zhu, Si-Yuan; Ma, Ding; Shao, Zhi-Ming; Yu, Ke-Da
通讯作者	Yu, KD (corresponding author), Fudan Univ, Dept Breast Surg, Shanghai Canc Ctr, Shanghai, Peoples R China. ; Yu, KD (corresponding author), Fudan Univ, Shanghai Med Coll, Shanghai, Peoples R China.
来源期刊	FRONTIERS IN MOLECULAR BIOSCIENCES
EISSN	2296-889X
出版年	2021
卷号	8
英文摘要	Background: The microenvironment of triple-negative breast cancer (TNBC) can be divided into three clusters based on bioinformatics-based immunogenomic analysis: the immune-desert cluster, the innate immune-inactivated cluster, and the immune-inflamed cluster. The immune-inflamed cluster is considered as hot tumor while the other two are considered as cold tumor. Methods: To investigate the prognostic effect of microenvironment phenotypes on TNBC, we compared relapse-free survival (RFS) of different phenotypes in 100 patients with RNA sequencing-based expression data from the PATTERN trial (NCT01216111, published in JAMA Oncol 2020), which indicated a superior efficacy of adjuvant paclitaxel-plus-carboplatin regimen compared to the regimen of cyclophosphamide/epirubicin/fluorouracil followed by docetaxel for TNBC. We also analyzed the efficacy of the two regimens for different immune phenotypes to explore potential treatment strategies. Results: No significant difference in RFS was observed between the hot tumor and the cold tumor (hazard ratio [HR] = 0.68, 95% confidence interval [CI] 0.28-1.66, P = 0.40). However, the hot tumor subtype was associated with significantly longer RFS in node-positive patients (HR = 0.27, 95%CI 0.07-0.97, P = 0.03). Consistently, a similar trend to improved RFS of the hot tumor phenotype was detected in patients with stage pT2-3 tumors (HR = 0.29, 95%CI 0.06-1.30, P = 0.08). Furthermore, no significant difference in RFS between the two treatment arms was observed in patients with hot tumor (HR = 0.39, 95% CI 0.08-2.01, P = 0.24) or cold tumor (HR = 1.05, 95% CI 0.39-2.82, P = 0.92). Conclusion: The microenvironment phenotype in TNBC might have prognostic significance to patients with a high risk of recurrence. The association of the microenvironment phenotypes with the efficacy of adjuvant chemotherapy for TNBC remains to be further studied.
英文关键词	triple-negative breast cancer microenvironment phenotype biomarker trial immune
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000703340800001
WOS关键词	TUMOR-INFILTRATING LYMPHOCYTES ; SUBTYPES
WOS类目	Biochemistry & Molecular Biology
WOS研究方向	Biochemistry & Molecular Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363326
作者单位	[Zhu, Si-Yuan; Ma, Ding; Shao, Zhi-Ming; Yu, Ke-Da] Fudan Univ, Dept Breast Surg, Shanghai Canc Ctr, Shanghai, Peoples R China; [Zhu, Si-Yuan; Yu, Ke-Da] Fudan Univ, Shanghai Med Coll, Shanghai, Peoples R China; [Shao, Zhi-Ming] Shanghai Key Lab Breast Canc, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Si-Yuan,Ma, Ding,Shao, Zhi-Ming,et al. Prognostic Effect of Microenvironment Phenotype in Triple-Negative Breast Cancer: Biomarker Analysis of a Prospective Trial[J],2021,8.
APA	Zhu, Si-Yuan,Ma, Ding,Shao, Zhi-Ming,&Yu, Ke-Da.(2021).Prognostic Effect of Microenvironment Phenotype in Triple-Negative Breast Cancer: Biomarker Analysis of a Prospective Trial.FRONTIERS IN MOLECULAR BIOSCIENCES,8.
MLA	Zhu, Si-Yuan,et al."Prognostic Effect of Microenvironment Phenotype in Triple-Negative Breast Cancer: Biomarker Analysis of a Prospective Trial".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021).