干旱区生态环境知识资源中心(Arid): Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer

Arid

DOI	10.3389/fimmu.2021.748221
	Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer
	Wu, JianBin; Zhu, Yuanyuan; Luo, MingMin; Li, Lei
通讯作者	Li, L (corresponding author), Univ Otago, Dept Pathol, Dunedin, New Zealand.
来源期刊	FRONTIERS IN IMMUNOLOGY
ISSN	1664-3224
出版年	2021
卷号	12
英文摘要	Background Immunotherapy has emerged as a significant strategy to treat numerous tumors. The positive response to immunotherapy depends on the dynamic interaction between tumor cells and infiltrating lymphocytes in the tumor microenvironment (TME). Pyroptosis, inflammation-induced cell death, is intricately associated with several tumors. However, the relationship between pyroptosis and clinical prognosis, immune cell infiltration, and immunotherapy effect is unclear in breast cancer (BRCA). Methods We comprehensively evaluated 33 pyroptosis-related genes and systematically assessed the relationship between pyroptosis and tumor progression, prognosis, and immune cell infiltration. The PyroptosisScore was used to quantify the pyroptosis pattern of a single tumor patient. We then assessed their values for predicting prognoses and therapeutic responses in BRCA. Results Three different modes of PyroptosisClusters were determined. The characteristics of TME cell infiltration in these three PyroptosisClusters were highly consistent with three immunophenotypes of tumors, including immune-excluded, immune-inflamed, and immune-desert phenotypes. Comprehensive bioinformatics analysis revealed that patients with a low PyroptosisScore had higher immune checkpoint expression, higher immune checkpoint inhibitor (ICI) scores, increased immune microenvironment infiltration, and were more sensitive to immunotherapy than those with a high PyroptosisScore. Conclusions Our findings revealed the crucial role of pyroptosis in maintaining the diversity and complexity of TME. Pyroptosis is closely related to tumor progression, tumor prognosis, and immunotherapy response. Evaluating the PyroptosisScore of a single tumor can assist in understanding the characteristics of TME infiltration and lead to the development of more effective immunotherapy strategies.
英文关键词	breast cancer pyroptosis tumor microenvironment immunotherapy immune checkpoint inhibitor (ICI)
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000709057000001
WOS关键词	BLOCKADE
WOS类目	Immunology
WOS研究方向	Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363316
作者单位	[Wu, JianBin] Fujian Med Univ, Affiliated Hosp, Fujian Matern & Child Hlth Hosp, Dept Breast, Fuzhou, Peoples R China; [Zhu, Yuanyuan] Beijing Univ Chinese Med, Dongzhimen Hosp, Sch Clin Med 1, Beijing, Peoples R China; [Luo, MingMin] Fujian Med Univ, Affiliated Hosp, Fujian Matern & Child Hlth Hosp, Reprod Med Ctr, Fuzhou, Peoples R China; [Li, Lei] Univ Otago, Dept Pathol, Dunedin, New Zealand
推荐引用方式 GB/T 7714	Wu, JianBin,Zhu, Yuanyuan,Luo, MingMin,et al. Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer[J],2021,12.
APA	Wu, JianBin,Zhu, Yuanyuan,Luo, MingMin,&Li, Lei.(2021).Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer.FRONTIERS IN IMMUNOLOGY,12.
MLA	Wu, JianBin,et al."Comprehensive Analysis of Pyroptosis-Related Genes and Tumor Microenvironment Infiltration Characterization in Breast Cancer".FRONTIERS IN IMMUNOLOGY 12(2021).