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| DOI | 10.3389/fcell.2021.689992 |
| Role of lncRNA BANCR in Human Cancers: An Updated Review | |
| Hussen, Bashdar Mahmud; Azimi, Tahereh; Abak, Atefe; Hidayat, Hazha Jamal; Taheri, Mohammad; Ghafouri-Fard, Soudeh | |
| 通讯作者 | Taheri, M (corresponding author), Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran. ; Ghafouri-Fard, S (corresponding author), Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran. |
| 来源期刊 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
 |
| ISSN | 2296-634X |
| 出版年 | 2021 |
| 卷号 | 9 |
| 英文摘要 | Being located in a gene desert region on 9q21.11-q21.12, BRAF-activated non-protein coding RNA (BANCR) is an lncRNA with 693 bp length. It has been discovered in 2012 in a research aimed at assessment of gene expression in the melanocytes in association with BRAF mutation. Increasing numbers of studies have determined its importance in the tumorigenesis through affecting cell proliferation, migration, invasion, apoptosis, and epithelial to mesenchymal transition. BANCR exerts its effects via modulating some tumor-related signaling pathways particularly MAPK and other regulatory mechanisms such as sponging miRNAs. BANCR has been up-regulated in endometrial, gastric, breast, melanoma, and retinoblastoma. Conversely, it has been down-regulated in some other cancers such as those originated from lung, bladder, and renal tissues. In some cancer types such as colorectal cancer, hepatocellular carcinoma and papillary thyroid carcinoma, there is no agreement about BANCR expression, necessitating the importance of additional functional studies in these tissues. In the present manuscript, we review the investigations related to BANCR expression changes in cancerous cell lines, clinical samples, and animal models of cancer. We also discuss the outcome of its deregulation in cancer progression, prognosis, and the underlying mechanisms of these observations. |
| 英文关键词 | BANCR lncRNA biomarker cancer expression |
| 类型 | Review |
| 语种 | 英语 |
| 开放获取类型 | Green Published, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000685123600010 |
| WOS关键词 | ACTIVATED NONCODING RNA ; COMPETING ENDOGENOUS RNA ; PAPILLARY THYROID-CANCER ; DOWN-REGULATION ; POOR-PROGNOSIS ; INCREASED EXPRESSION ; CELL-PROLIFERATION ; TUMOR PROGRESSION ; UP-REGULATION ; BRAF |
| WOS类目 | Cell Biology ; Developmental Biology |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/363274 |
| 作者单位 | [Hussen, Bashdar Mahmud] Hawler Med Univ, Dept Pharmacognosy, Coll Pharm, Erbil, Iraq; [Azimi, Tahereh] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran; [Abak, Atefe] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran; [Hidayat, Hazha Jamal] Salahadddin Univ Erbil, Dept Biol, Coll Educ, Erbil, Iraq; [Taheri, Mohammad] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran; [Ghafouri-Fard, Soudeh] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran |
| 推荐引用方式 GB/T 7714 | Hussen, Bashdar Mahmud,Azimi, Tahereh,Abak, Atefe,et al. Role of lncRNA BANCR in Human Cancers: An Updated Review[J],2021,9. |
| APA | Hussen, Bashdar Mahmud,Azimi, Tahereh,Abak, Atefe,Hidayat, Hazha Jamal,Taheri, Mohammad,&Ghafouri-Fard, Soudeh.(2021).Role of lncRNA BANCR in Human Cancers: An Updated Review.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9. |
| MLA | Hussen, Bashdar Mahmud,et al."Role of lncRNA BANCR in Human Cancers: An Updated Review".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2021). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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