干旱区生态环境知识资源中心(Arid): Multi-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each Other

Arid

DOI	10.3389/fnagi.2021.675016
	Multi-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each Other
	Choi, Yu Yong; Lee, Jang Jae; Choi, Kyu Yeong; Choi, Uk-Su; Seo, Eun Hyun; Choo, I. L. Han; Kim, Hoowon; Song, Min-Kyung; Choi, Seong-Min; Cho, Soo Hyun; Choe, Youngshik; Kim, Byeong C.; Lee, Kun Ho
通讯作者	Lee, KH (corresponding author), Chosun Univ, Gwangju Alzheimers Dis & Related Dementia Cohort, Gwangju, South Korea. ; Kim, BC (corresponding author), Chonnam Natl Univ, Med Sch & Hosp, Dept Neurol, Gwangju, South Korea. ; Lee, KH (corresponding author), Korea Brain Res Inst, Daegu, South Korea. ; Lee, KH (corresponding author), Chosun Univ, Dept Biomed Sci, Gwangju, South Korea. ; Lee, KH (corresponding author), Neurozen Inc, Seoul, South Korea.
来源期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
出版年	2021
卷号	13
英文摘要	Brain aging is becoming an increasingly important topic, and the norms of brain structures are essential for diagnosing neurodegenerative diseases. However, previous studies of the aging brain have mostly focused on Caucasians, not East Asians. The aim of this paper was to examine ethnic differences in the aging process of brain structures or to determine to what extent ethnicity affects the normative values of lobar and subcortical volumes in clinically normal elderly and the diagnosis in multi-racial patients with Alzheimer's disease (AD). Lobar and subcortical volumes were measured using FreeSurfer from MRI data of 1,686 normal Koreans (age range 59-89) and 851 Caucasian, non-Hispanic subjects in the ADNI and OASIS datasets. The regression models were designed to predict brain volumes, including ethnicity, age, sex, intracranial volume (ICV), magnetic field strength (MFS), and MRI scanner manufacturers as independent variables. Ethnicity had a significant effect for all lobar (vertical bar beta vertical bar > 0.20, p < 0.001) and subcortical regions (vertical bar beta vertical bar > 0.08, p < 0.001) except left pallidus and bilateral ventricles. To demonstrate the validity of the z-score for AD diagnosis, 420 patients and 420 normal controls were selected evenly from the Korean and Caucasian datasets. The four validation groups divided by race and diagnosis were matched on age and sex using a propensity score matching. We analyzed whether and to what extent the ethnicity adjustment improved the diagnostic power of the logistic regression model that was built using the only z-scores of six regions: bilateral temporal cortices, hippocampi, and amygdalae. The performance of the classifier after ethnicity adjustment was significantly improved compared with the classifier before ethnicity adjustment (Delta AUC = 0.10, D = 7.80, p < 0.001; AUC comparison test using bootstrap). Korean AD dementia patients may not be classified by Caucasian norms of brain volumes because the brain regions vulnerable to AD dementia are bigger in normal Korean elderly peoples. Therefore, ethnicity is an essential factor in establishing normative data for regional volumes in brain aging and applying it to the diagnosis of neurodegenerative diseases.
英文关键词	aging norm ethnic difference Alzheimer's disease brain magnetic resonance imaging
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000685495200001
WOS关键词	SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; SEGMENTATION ; MORPHOLOGY ; THICKNESS ; LIFETIME ; DISEASE ; REGIONS ; ATROPHY ; SYSTEM
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363272
作者单位	[Choi, Yu Yong; Lee, Jang Jae; Choi, Kyu Yeong; Choi, Uk-Su; Seo, Eun Hyun; Kim, Hoowon; Lee, Kun Ho] Chosun Univ, Gwangju Alzheimers Dis & Related Dementia Cohort, Gwangju, South Korea; [Choi, Yu Yong; Kim, Hoowon] Chosun Univ Hosp, Biomed Technol Ctr, Gwangju, South Korea; [Choo, I. L. Han] Chosun Univ, Sch Med & Hosp, Dept Neuropsychiat, Gwangju, South Korea; [Kim, Hoowon] Chosun Univ, Sch Med & Hosp, Dept Neurol, Gwangju, South Korea; [Song, Min-Kyung; Choi, Seong-Min; Cho, Soo Hyun; Kim, Byeong C.] Chonnam Natl Univ, Med Sch & Hosp, Dept Neurol, Gwangju, South Korea; [Choe, Youngshik; Lee, Kun Ho] Korea Brain Res Inst, Daegu, South Korea; [Lee, Kun Ho] Chosun Univ, Dept Biomed Sci, Gwangju, South Korea; [Lee, Kun Ho] Neurozen Inc, Seoul, South Korea
推荐引用方式 GB/T 7714	Choi, Yu Yong,Lee, Jang Jae,Choi, Kyu Yeong,et al. Multi-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each Other[J],2021,13.
APA	Choi, Yu Yong.,Lee, Jang Jae.,Choi, Kyu Yeong.,Choi, Uk-Su.,Seo, Eun Hyun.,...&Lee, Kun Ho.(2021).Multi-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each Other.FRONTIERS IN AGING NEUROSCIENCE,13.
MLA	Choi, Yu Yong,et al."Multi-Racial Normative Data for Lobar and Subcortical Brain Volumes in Old Age: Korean and Caucasian Norms May Be Incompatible With Each Other".FRONTIERS IN AGING NEUROSCIENCE 13(2021).