干旱区生态环境知识资源中心(Arid): New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara)

Arid

DOI	10.1016/j.fitote.2021.105041
	New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara)
	Uushona, Nashipolo E.; Dziwornu, Godwin A.; Mkwanazi, Nonkululeko; Kaschula, Catherine H.; Sunassee, Suthananda N.; de Villiers, Andre
通讯作者	de Villiers, A (corresponding author), Stellenbosch Univ, Dept Chem & Polymer Sci, Private Bag X1, ZA-7602 Matieland, South Africa.
来源期刊	FITOTERAPIA
ISSN	0367-326X
EISSN	1873-6971
出版年	2021
卷号	155
英文摘要	Acanthosicyos horridus Welw. ex Hook.f. (!nara) is a leafless, thorny, melon-producing plant endemic to the hyper-arid Namib Desert. The methanol crude extract prepared from the ripe fruits of !nara afforded the known dihydroxycucurbitacin 7fl-hydroxy-23,24-dihydrocucurbitacin D (1), along with four new congeners 7fl,15fl-dihydroxy-23,24-dihydrocucurbitacin D (2), 25-O-fl-glucopyranosyl-7fl-hydroxy-23,24-dihydrocucurbitacin D (3), 25-O-fl-glucopyranosyl-7fl-hydroxy-23,24-dihydroisocucurbitacin D (4) and 25-O-fl-glucopyranosyl-7fl-hy-droxy-23,24-dihydro-3-epi-isocucurbitacin D (5). These compounds were isolated through a combination of preparative normal phase thin-layer chromatography (TLC) and semi-preparative reversed phase high performance liquid chromatography (HPLC). Their structures were established by comprehensive analysis of HR-ESIMS data, 1D and 2D NMR spectroscopic data and by comparison with literature values of similar cucurbitacins. The five isolated compounds exhibited poor cytotoxic activity against the MDA-MB-231 breast cancer cell line. To the best of our knowledge, this is the first report of glycosylated cucurbitacins in Acanthosicyos horridus.
英文关键词	Acanthosicyos horridus (!nara) cucurbitacins cucurbitacin-glycosides cytotoxicity dihydrocucurbitacin D Namib desert
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000705657600001
WOS关键词	CUCURBITACIN GLYCOSIDES ; NMR-SPECTROSCOPY ; ASSIGNMENT ; ANTICANCER ; H-1
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363240
作者单位	[Uushona, Nashipolo E.; Mkwanazi, Nonkululeko; Kaschula, Catherine H.; de Villiers, Andre] Stellenbosch Univ, Dept Chem & Polymer Sci, Private Bag X1, ZA-7602 Matieland, South Africa; [Dziwornu, Godwin A.; Sunassee, Suthananda N.] Univ Cape Town, Dept Chem, ZA-7700 Rondebosch, South Africa
推荐引用方式 GB/T 7714	Uushona, Nashipolo E.,Dziwornu, Godwin A.,Mkwanazi, Nonkululeko,et al. New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara)[J],2021,155.
APA	Uushona, Nashipolo E.,Dziwornu, Godwin A.,Mkwanazi, Nonkululeko,Kaschula, Catherine H.,Sunassee, Suthananda N.,&de Villiers, Andre.(2021).New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara).FITOTERAPIA,155.
MLA	Uushona, Nashipolo E.,et al."New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara)".FITOTERAPIA 155(2021).