干旱区生态环境知识资源中心(Arid): Phytomedicine from Middle Eastern Countries: An Alternative Remedy to Modern Medicine against Candida spp Infection

Arid

DOI	10.1155/2021/6694876
	Phytomedicine from Middle Eastern Countries: An Alternative Remedy to Modern Medicine against Candida spp Infection
	Alam, Mohammad Zubair; Ahmad Khan, Mohd Sajjad
通讯作者	Alam, MZ (corresponding author), King Abdulaziz Univ, King Fahad Med Res Ctr, Preclin Res Unit, Jeddah 21589, Saudi Arabia. ; Alam, MZ (corresponding author), King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah 21589, Saudi Arabia. ; Khan, MSA (corresponding author), Imam Abdulrahman Bin Faisal Univ, Dept Basic Sci, Preparatory Year & Supporting Studies, POB 1982, Dammam 34212, Saudi Arabia.
来源期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN	1741-427X
EISSN	1741-4288
出版年	2021
卷号	2021
英文摘要	Candida spp are capable of infecting both normal and immunocompromised individuals. More recently, Candida infections have spread considerably in healthcare settings, especially in intensive care units, where it is the most frequently encountered pathogen. Candida albicans is the commonest species encountered, although infections by non-albicans species have also risen in the past few years. The pathogenicity of Candida is credited to its aptitude to change between yeast and hyphal modes of growth. Candida spp produce biofilms on synthetic materials that protect them and facilitate drug resistance and act as a source for chronic and recurrent infections. Primarily, azoles antifungal agents are utilized to treat Candida infection that targets the ergosterol synthesis pathway in the cell wall. The development of antifungal resistance in Candida species is a major reason for treatment failure, and hence, there is a need to develop newer antifungal molecules and/or modifications of existing antifungals to make them more effective and less toxic. This has led researchers to oversee the plants to discover newer antimicrobials. Middle Eastern countries are well known for their landscape ranging from dry and sandy deserts to snow-capped mountains. However, they comprise enormous plant diversity with over 20,000 different species showing various types of bioactivities, such as anticancer, antidiabetic, and antimicrobial activities. Especially, the antifungal potential of these phytoproducts could be exploited in the clinical setting for therapy. The present review examines some of the promising alternative natural compounds that have been tested and found effective in treating Candida infections in vitro in some Middle Eastern countries.
类型	Review
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000680521900003
WOS关键词	ESSENTIAL OIL COMPOSITION ; CHEMICAL-COMPOSITION ; ANTIMICROBIAL ACTIVITIES ; ANTIFUNGAL ACTIVITIES ; BIOLOGICAL-ACTIVITIES ; ANTICANDIDAL ACTIVITY ; ACHILLEA-MILLEFOLIUM ; TRADITIONAL MEDICINE ; PLANTS ; EXTRACT
WOS类目	Integrative & Complementary Medicine
WOS研究方向	Integrative & Complementary Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363221
作者单位	[Alam, Mohammad Zubair] King Abdulaziz Univ, King Fahad Med Res Ctr, Preclin Res Unit, Jeddah 21589, Saudi Arabia; [Alam, Mohammad Zubair] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah 21589, Saudi Arabia; [Ahmad Khan, Mohd Sajjad] Imam Abdulrahman Bin Faisal Univ, Dept Basic Sci, Preparatory Year & Supporting Studies, POB 1982, Dammam 34212, Saudi Arabia
推荐引用方式 GB/T 7714	Alam, Mohammad Zubair,Ahmad Khan, Mohd Sajjad. Phytomedicine from Middle Eastern Countries: An Alternative Remedy to Modern Medicine against Candida spp Infection[J],2021,2021.
APA	Alam, Mohammad Zubair,&Ahmad Khan, Mohd Sajjad.(2021).Phytomedicine from Middle Eastern Countries: An Alternative Remedy to Modern Medicine against Candida spp Infection.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021.
MLA	Alam, Mohammad Zubair,et al."Phytomedicine from Middle Eastern Countries: An Alternative Remedy to Modern Medicine against Candida spp Infection".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021(2021).