干旱区生态环境知识资源中心(Arid): Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis

Arid

DOI	10.1192/j.eurpsy.2021.2222
	Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis
	de Pablo, Gonzalo Salazar; Davies, Cathy; de Diego, Hector; Solmi, Marco; Shin, Jae Il; Carvalho, Andre F.; Radua, Joaquim; Fusar-Poli, Paolo
通讯作者	de Pablo, GS (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England. ; de Pablo, GS (corresponding author), Univ Complutense, Inst Invest Sanitaria Gregorio Maranon IiSGM, Hosp Gen Univ Gregorio Maranon,Inst Psychiat & Me, CIBERSAM,Sch Med,Dept Child & Adolescent Psychiat, Madrid, Spain. ; de Pablo, GS (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, London, England.
来源期刊	EUROPEAN PSYCHIATRY
ISSN	0924-9338
EISSN	1778-3585
出版年	2021
卷号	64 期号:1
英文摘要	Background Individuals at clinical high risk of psychosis (CHR-P) recruited in randomized clinical trials (RCTs) and observational cohorts may display a different enrichment and hence risk of transition to psychosis. No meta-analysis has ever addressed this issue. Methods Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) and Meta-analysis Of Observational Studies in Epidemiology (MOOSE)-compliant meta-analysis. PubMed and Web of Science were searched until November 2020 (PROSPERO:CRD42021229223). We included nonoverlapping longitudinal studies (RCTs-control condition and observational cohorts) reporting the transition to psychosis in CHR-P individuals. The primary effect size measure was the cumulative risk of transition at 0.5, 1, and 2 years follow-up in RCTs compared to observational cohorts. Random effects meta-analyses, heterogeneity assessment, quality assessment, and meta-regressions were conducted. Results Ninety-four independent studies (24 RCTs, 70 observational cohorts) and 9,243 individuals (mean age = 20.1 +/- 3.0 years; 43.7% females) were included. The meta-analytical risk of transitioning to psychosis from a CHR-P stage was 0.091 (95% confidence intervals [CI] = 0.068-0.121) at 0.5 years, 0.140 (95% CI = 0.101-0.191) at 1 year and 0.165 (95% CI = 0.097-0.267) at 2 years follow-up in RCTs, and 0.081 (95% CI = 0.067-0.099) at 0.5 years, 0.138 (95% CI = 0.114-0.167) at 1 year, and 0.174 (95% CI = 0.156-0.193) at 2 years follow-up in observational cohorts. There were no between-group differences in transition risks (p > 0.05). The proportion of CHR-P individuals with substance use disorders (excluding alcohol and cannabis) was higher in observational cohorts (16.8, 95% CI = 13.3-21.0%) than in RCTs (3.4, 95% CI = 0.8-12.7%; p = 0.018). Conclusions There is no meta-analytic evidence supporting sampling biases in RCTs of CHR-P individuals. Further RCTs are needed to detect effective interventions to prevent psychosis in this at-risk group.
英文关键词	Psychosis schizophrenia risk Transition CHR Meta-analysis
类型	Review
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000687625400001
WOS关键词	ULTRA-HIGH RISK ; SOUTH-LONDON OASIS ; 1ST-EPISODE PSYCHOSIS ; YOUNG-PEOPLE ; AT-RISK ; PREVENTION ; SYMPTOMS ; PLACEBO ; SERVICE ; INTERVENTIONS
WOS类目	Psychiatry
WOS研究方向	Psychiatry
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363219
作者单位	[de Pablo, Gonzalo Salazar; Davies, Cathy; Solmi, Marco; Radua, Joaquim; Fusar-Poli, Paolo] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England; [de Pablo, Gonzalo Salazar; de Diego, Hector] Univ Complutense, Inst Invest Sanitaria Gregorio Maranon IiSGM, Hosp Gen Univ Gregorio Maranon,Inst Psychiat & Me, CIBERSAM,Sch Med,Dept Child & Adolescent Psychiat, Madrid, Spain; [de Pablo, Gonzalo Salazar; de Diego, Hector] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, London, England; [Solmi, Marco] Univ Ottawa, Ottawa Hosp, Dept Psychiat, Dept Mental Hlth, Ottawa, ON, Canada; [Shin, Jae Il] Yonsei Univ, Dept Paediat, Coll Med, Seoul, South Korea; [Carvalho, Andre F.] Deakin Univ, IMPACT Innovat Mental & Phys Hlth & Clin Treatmen, Sch Med, Barwon Hlth, Geelong, Vic, Australia; [Radua, Joaquim] Inst Invest Biomed August Pi & Sunyer IDIBAPS, CIBERSAM, Imaging Mood & Anxiety Related Diso...
推荐引用方式 GB/T 7714	de Pablo, Gonzalo Salazar,Davies, Cathy,de Diego, Hector,et al. Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis[J]. University of London,2021,64(1).
APA	de Pablo, Gonzalo Salazar.,Davies, Cathy.,de Diego, Hector.,Solmi, Marco.,Shin, Jae Il.,...&Fusar-Poli, Paolo.(2021).Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis.EUROPEAN PSYCHIATRY,64(1).
MLA	de Pablo, Gonzalo Salazar,et al."Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis".EUROPEAN PSYCHIATRY 64.1(2021).