干旱区生态环境知识资源中心(Arid): Mechanisms underlying the health effects of desert sand dust

Arid

DOI	10.1016/j.envint.2021.106790
	Mechanisms underlying the health effects of desert sand dust
	Fussell, Julia C.; Kelly, Frank J.
通讯作者	Fussell, JC (corresponding author), Imperial Coll London, Sch Publ Hlth, Natl Inst Hlth Res, Hlth Protect Res Unit Environm Exposures & Hlth, Sir Michael Uren Bldg,White City Campus, London W12 0BZ, England.
来源期刊	ENVIRONMENT INTERNATIONAL
ISSN	0160-4120
EISSN	1873-6750
出版年	2021
卷号	157
英文摘要	Desertification and climate change indicate a future expansion of the global area of dry land and an increase in the risk of drought. Humans may therefore be at an ever-increasing risk of frequent exposure to, and resultant adverse health effects of desert sand dust. This review appraises a total of 52 experimental studies that have sought to identify mechanisms and intermediate endpoints underlying epidemiological evidence of an impact of desert dust on cardiovascular and respiratory health. Toxicological studies, in main using doses that reflect or at least approach real world exposures during a dust event, have demonstrated that virgin sand dust particles and dust storm particles sampled at remote locations away from the source induce inflammatory lung injury and aggravate allergen-induced nasal and pulmonary eosinophilia. Effects are orchestrated by cytokines, chemokines and antigen-specific immunoglobulin potentially via toll-like receptor/myeloid differentiation factor signaling pathways. Findings suggest that in addition to involvement of adhered chemical and biological pollutants, mineralogical components may also be implicated in the pathogenesis of human respiratory disorders during a dust event. Whilst comparisons with urban particulate matter less than 2.5 mu m in diameter (PM2.5) suggest that allergic inflammatory responses are greater for microbial element-rich dust-PM2.5, aerosols generated during dust events appear to have a lower oxidative potential compared to combustion-generated PM2.5 sampled during non-dust periods. In vitro findings suggest that the significant amounts of suspended desert dust during storm periods may provide a platform to intermix with chemicals on its surfaces, thereby increasing the bioreactivity of PM2.5 during dust storm episodes, and that mineral dust surface reactions are an unrecognized source of toxic organic chemicals in the atmosphere, enhancing toxicity of aerosols in urban environments. In summary, the experimental research on desert dust on respiratory endpoints go some way in clarifying the mechanistic effects of atmospheric desert dust on the upper and lower human respiratory system. In doing so, they provide support for biological plausibility of epidemiological associations between this particulate air pollutant and events including exacerbation of asthma, hospitalization for respiratory infections and seasonal allergic rhinitis.
英文关键词	Allergic respiratory disease Asian sand dust Cardiovascular disease Desert dust Inflammation Microbial materials Oxidative stress Toxicology
类型	Article
语种	英语
开放获取类型	hybrid
收录类别	SCI-E
WOS记录号	WOS:000704786000008
WOS关键词	RESPIRATORY EPITHELIAL-CELLS ; MUCIN GENE-EXPRESSION ; PULMONARY TOXICITY ; ASIAN DUST ; OXIDATIVE STRESS ; INTRATRACHEAL INSTILLATION ; ALLERGIC INFLAMMATION ; AIRWAY INFLAMMATION ; SIZE DISTRIBUTION ; ZINC-DEFICIENCY
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363095
作者单位	[Fussell, Julia C.; Kelly, Frank J.] Imperial Coll London, Sch Publ Hlth, Natl Inst Hlth Res, Hlth Protect Res Unit Environm Exposures & Hlth, Sir Michael Uren Bldg,White City Campus, London W12 0BZ, England
推荐引用方式 GB/T 7714	Fussell, Julia C.,Kelly, Frank J.. Mechanisms underlying the health effects of desert sand dust[J],2021,157.
APA	Fussell, Julia C.,&Kelly, Frank J..(2021).Mechanisms underlying the health effects of desert sand dust.ENVIRONMENT INTERNATIONAL,157.
MLA	Fussell, Julia C.,et al."Mechanisms underlying the health effects of desert sand dust".ENVIRONMENT INTERNATIONAL 157(2021).