干旱区生态环境知识资源中心(Arid): Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila

Arid

DOI	10.7554/eLife.68656
	Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila
	Elliott, Amicia D.; Berndt, Adama; Houpert, Matthew; Roy, Snehashis; Scott, Robert L.; Chow, Carson C.; Shroff, Hari; White, Benjamin H.
通讯作者	White, BH (corresponding author), NIMH, NIH, Bethesda, MD 20892 USA.
来源期刊	ELIFE
ISSN	2050-084X
出版年	2021
卷号	10
英文摘要	Identifying neural substrates of behavior requires defining actions in terms that map onto brain activity. Brain and muscle activity naturally correlate via the output of motor neurons, but apart from simple movements it has been difficult to define behavior in terms of muscle contractions. By mapping the musculature of the pupal fruit fly and comprehensively imaging muscle activation at single-cell resolution, we here describe a multiphasic behavioral sequence in Drosophila. Our characterization identifies a previously undescribed behavioral phase and permits extraction of major movements by a convolutional neural network. We deconstruct movements into a syllabary of co-active muscles and identify specific syllables that are sensitive to neuromodulatory manipulations. We find that muscle activity shows considerable variability, with sequential increases in stereotypy dependent upon neuromodulation. Our work provides a platform for studying wholeanimal behavior, quantifying its variability across multiple spatiotemporal scales, and analyzing its neuromodulatory regulation at cellular resolution.
类型	Article
语种	英语
开放获取类型	Green Submitted, Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000683009900001
WOS关键词	IMAGINAL ECDYSIS ; SCHISTOCERCA-GREGARIA ; DESERT LOCUST ; NEUROMUSCULAR-JUNCTIONS ; CELLULAR RESOLUTION ; HORMONAL-CONTROL ; METAMORPHOSIS ; PATTERNS ; ORGANIZATION ; MATURATION
WOS类目	Biology
WOS研究方向	Life Sciences & Biomedicine - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/363063
作者单位	[Elliott, Amicia D.; Berndt, Adama; Houpert, Matthew; Roy, Snehashis; Scott, Robert L.; White, Benjamin H.] NIMH, NIH, Bethesda, MD 20892 USA; [Elliott, Amicia D.; Shroff, Hari] Natl Inst Biomed Imaging & Bioengn, NIH, Bethesda, MD USA; [Chow, Carson C.] NIDDK, NIH, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Elliott, Amicia D.,Berndt, Adama,Houpert, Matthew,et al. Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila[J],2021,10.
APA	Elliott, Amicia D..,Berndt, Adama.,Houpert, Matthew.,Roy, Snehashis.,Scott, Robert L..,...&White, Benjamin H..(2021).Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila.ELIFE,10.
MLA	Elliott, Amicia D.,et al."Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila".ELIFE 10(2021).