干旱区生态环境知识资源中心(Arid): Gas Chromatography Multiresidue Method for Enantiomeric Fraction Determination of Psychoactive Substances in Effluents and River Surface Waters

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DOI	10.3390/chemosensors9080224
	Gas Chromatography Multiresidue Method for Enantiomeric Fraction Determination of Psychoactive Substances in Effluents and River Surface Waters
	Langa, Ivan; Tiritan, Maria Elizabeth; Silva, Diana; Ribeiro, Claudia
通讯作者	Tiritan, ME ; Ribeiro, C (corresponding author), Inst Invest & Formacao Avancada Ciencias & Tecnol, CESPU, Rua Cent Gandra 1317, P-4585116 Gandra, Portugal. ; Tiritan, ME ; Ribeiro, C (corresponding author), Univ Inst Hlth Sci, CESPU, CRL, TOXRUN Toxicol Res Unit, P-4585116 Gandra, Portugal. ; Tiritan, ME ; Ribeiro, C (corresponding author), Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental C, Edificio Terminal Cruzeiros Porto Leixoes, P-4050208 Matosinhos, Portugal. ; Tiritan, ME (corresponding author), Univ Porto, Lab Quim Organ & Farmaceut, Dept Ciencias Quim, Fac Farm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal.
来源期刊	CHEMOSENSORS
EISSN	2227-9040
出版年	2021
卷号	9 期号:8
英文摘要	Determination of psychoactive substances (PAS) and/or their metabolites in surface waters is crucial for environmental risk assessment, and disclosure of their enantiomeric fractions (EF) allows discrimination between consumption, direct disposal, and synthesis pathways. The aim of this study was to develop and validate an indirect method by gas chromatography coupled to mass spectrometry (GC-MS) based on derivatization using (R)-(-)-alpha-methoxy-alpha-(trifluoromethyl) phenylacetyl chloride as chiral derivatization reagent, for enantiomeric quantification of amphetamine (AMP), methamphetamine (MAMP), 3,4-methylenedioxymethamphetamine (MDMA), norketamine, buphedrone (BPD), butylone, 3,4-dimethylmethcathinone (3,4-DMMC), 3-methylmethcathinone, and quantification of 1-benzylpiperazine and 1-(4-metoxyphenyl)-piperazine. The method allowed to evaluate the occurrence, spatial distribution, and the EF of the target chiral PAS in Portuguese surface waters and in effluents from 2 wastewater treatment plants (WWTP). For that, water samples were pre-concentrated by solid phase extraction using OASIS (R) MCX cartridges, derivatized and further analyzed by GC-MS. Both enantiomers of AMP, (R)-MDMA, (S)-MAMP, and the first eluted enantiomer of BPD (configuration not assigned) were found in surface waters, while effluent samples showed both enantiomers of MDMA, (S)-MAMP, (R)-AMP, and the first eluted enantiomer of BPD and 3,4-DMMC. According to our knowledge, this is the first multiresidue analytical method by CG-MS enrolling cathinones, amphetamines, and piperazines. The presence of illicit synthetic cathinones in Douro River estuary is here reported for the first time, along with other amphetamine derivatives. The potential of the method to monitor consumption of the target PAS was demonstrated.
英文关键词	synthetic cathinones amphetamines estuarine water psychoactive drugs enantioselective wastewater treatment plants
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000688825400001
WOS关键词	WASTE-WATER ; ILLICIT DRUGS ; LIQUID-CHROMATOGRAPHY ; ENANTIOSELECTIVE DEGRADATION ; TREATMENT PLANTS ; METHAMPHETAMINE ; PHARMACEUTICALS ; BIODEGRADATION ; EPIDEMIOLOGY ; AMPHETAMINE
WOS类目	Chemistry, Analytical ; Electrochemistry ; Instruments & Instrumentation
WOS研究方向	Chemistry ; Electrochemistry ; Instruments & Instrumentation
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362847
作者单位	[Langa, Ivan; Tiritan, Maria Elizabeth; Silva, Diana; Ribeiro, Claudia] Inst Invest & Formacao Avancada Ciencias & Tecnol, CESPU, Rua Cent Gandra 1317, P-4585116 Gandra, Portugal; [Langa, Ivan; Tiritan, Maria Elizabeth; Silva, Diana; Ribeiro, Claudia] Univ Inst Hlth Sci, CESPU, CRL, TOXRUN Toxicol Res Unit, P-4585116 Gandra, Portugal; [Tiritan, Maria Elizabeth; Ribeiro, Claudia] Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental C, Edificio Terminal Cruzeiros Porto Leixoes, P-4050208 Matosinhos, Portugal; [Tiritan, Maria Elizabeth] Univ Porto, Lab Quim Organ & Farmaceut, Dept Ciencias Quim, Fac Farm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal; [Silva, Diana] Univ Porto, Fac Pharm, Lab Toxicol, UCIBIO,REQUIMTE, R Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal
推荐引用方式 GB/T 7714	Langa, Ivan,Tiritan, Maria Elizabeth,Silva, Diana,et al. Gas Chromatography Multiresidue Method for Enantiomeric Fraction Determination of Psychoactive Substances in Effluents and River Surface Waters[J],2021,9(8).
APA	Langa, Ivan,Tiritan, Maria Elizabeth,Silva, Diana,&Ribeiro, Claudia.(2021).Gas Chromatography Multiresidue Method for Enantiomeric Fraction Determination of Psychoactive Substances in Effluents and River Surface Waters.CHEMOSENSORS,9(8).
MLA	Langa, Ivan,et al."Gas Chromatography Multiresidue Method for Enantiomeric Fraction Determination of Psychoactive Substances in Effluents and River Surface Waters".CHEMOSENSORS 9.8(2021).