干旱区生态环境知识资源中心(Arid): Isosalipurposide: A Promising Analgesic, Anti-inflammatory and Gastroprotective Agent Isolated from the Flowers of Acacia cyanophylla

Arid

DOI	10.1007/s42250-021-00247-7
	Isosalipurposide: A Promising Analgesic, Anti-inflammatory and Gastroprotective Agent Isolated from the Flowers of Acacia cyanophylla
	Ghribi, Lotfi; Deghrigue, Monia; Znati, Mansour; Bouraoui, Abderrahman; Ben Jannet, Hichem
通讯作者	Znati, M (corresponding author), Univ Monastir, Fac Sci Monastir, Team Med Chem & Nat Prod, Lab Heterocycl Chem Nat Prod & React LR11ES39, Monastir 5019, Tunisia.
来源期刊	CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
ISSN	2522-5758
EISSN	2522-5766
出版年	2021
卷号	4 期号:3 页码:483-490
英文摘要	The importance of the Acacia genus is due to its usage in nutrition, and in folk and modern medicine. They are considered as promising sources of bioactive metabolites displaying beneficial to human health. The chemical and biological investigation of some Acacia species helped in the design of food supplements and drugs. A. cyanophylla has been introduced in Tunisia mainly to rehabilitate rangelands, especially in semi-arid areas, and also as a potential forage resource during periods of drought. The aim of this study was to investigate, in vivo, the analgesic, anti-inflammatory and gastroprotective potentials of the EtOAc extract and one of its major glycoside constituents, isosalipurposide (1), from the flowers of A. cyanophylla. The gastroprotective activity was evaluated using HCl/EtOH induced gastric ulcers in rats. The EtOAc extract exhibited interesting gastroprotective, analgesic and anti-inflammatory activities in a dose-dependent manner. Similarly, isosalipurposide (1) displayed promising anti-inflammatory and analgesic potentials and showed a protection of stomach against ulcer induced by HCl/EtOH. These data suggest that the pharmacological potential of the EtOAc extract could be mainly due to its main component isosalipurposide (1), which leads to conclude that the flowers of A. cyanophylla may be a possible source for the quantitative isolation of a pharmacoactive compound of interest.
英文关键词	Acacia cyanophylla EtOAc extract Isosalipurposide Pharmacological activities
类型	Article
语种	英语
收录类别	ESCI
WOS记录号	WOS:000688153800001
WOS关键词	CHALCONE ; ROOTS
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362846
作者单位	[Ghribi, Lotfi; Znati, Mansour; Ben Jannet, Hichem] Univ Monastir, Fac Sci Monastir, Team Med Chem & Nat Prod, Lab Heterocycl Chem Nat Prod & React LR11ES39, Monastir 5019, Tunisia; [Deghrigue, Monia; Bouraoui, Abderrahman] Univ Monastir, Fac Pharm Monastir, Lab Chem Galen & Pharmacol Drug Dev LR12ES09, Monastir 5000, Tunisia
推荐引用方式 GB/T 7714	Ghribi, Lotfi,Deghrigue, Monia,Znati, Mansour,et al. Isosalipurposide: A Promising Analgesic, Anti-inflammatory and Gastroprotective Agent Isolated from the Flowers of Acacia cyanophylla[J],2021,4(3):483-490.
APA	Ghribi, Lotfi,Deghrigue, Monia,Znati, Mansour,Bouraoui, Abderrahman,&Ben Jannet, Hichem.(2021).Isosalipurposide: A Promising Analgesic, Anti-inflammatory and Gastroprotective Agent Isolated from the Flowers of Acacia cyanophylla.CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY,4(3),483-490.
MLA	Ghribi, Lotfi,et al."Isosalipurposide: A Promising Analgesic, Anti-inflammatory and Gastroprotective Agent Isolated from the Flowers of Acacia cyanophylla".CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY 4.3(2021):483-490.