干旱区生态环境知识资源中心(Arid): Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer

Arid

DOI	10.1016/j.ccell.2021.04.004
	Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer
	Hornburg, Milena; Desbois, Melanie; Lu, Shan; Guan, Yinghui; Lo, Amy A.; Kaufman, Susan; Elrod, Ashley; Lotstein, Alina; DesRochers, Teresa M.; Munoz-Rodriguez, Jose L.; Wang, Xingwei; Giltnane, Jennifer; Mayba, Oleg; Turley, Shannon J.; Bourgon, Richard; Daemen, Anneleen; Wang, Yulei
通讯作者	Wang, YL (corresponding author), Genentech Inc, Dept Oncol Biomarker Dev, San Francisco, CA 94080 USA.
来源期刊	CANCER CELL
ISSN	1535-6108
EISSN	1878-3686
出版年	2021
卷号	39 期号:7 页码:928-+
英文摘要	Distinct T cell infiltration patterns, i.e., immune infiltrated, excluded, and desert, result in different responses to cancer immunotherapies. However, the key determinants and biology underpinning these tumor immune phenotypes remain elusive. Here, we provide a high-resolution dissection of the entire tumor ecosystem through single-cell RNA-sequencing analysis of 15 ovarian tumors. Immune-desert tumors are characterized by unique tumor cell-intrinsic features, including metabolic pathways and low antigen presentation, and an enrichment of monocytes and immature macrophages. Immune-infiltrated and -excluded tumors differ markedly in their T cell composition and fibroblast subsets. Furthermore, our study reveals chemokine receptor-ligand interactions within and across compartments as potential mechanisms mediating immune cell infiltration, exemplified by the tumor cell-T cell cross talk via CXCL16-CXCR6 and stromal-immune cell cross talk via CXCL12/14-CXCR4. Our data highlight potential molecular mechanisms that shape the tumor immune phenotypes and may inform therapeutic strategies to improve clinical benefit from cancer immunotherapies.
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000672680500012
WOS关键词	INFILTRATING T-CELLS ; EXPRESSION ; LANDSCAPE ; HETEROGENEITY ; BEVACIZUMAB ; MACROPHAGES ; RESISTANCE ; SUBSETS ; CXCL14 ; STROMA
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362774
作者单位	[Hornburg, Milena; Mayba, Oleg; Bourgon, Richard; Daemen, Anneleen] Genentech Inc, Dept Bioinformat & Computat Biol, San Francisco, CA 94080 USA; [Desbois, Melanie; Lu, Shan; Guan, Yinghui; Wang, Yulei] Genentech Inc, Dept Oncol Biomarker Dev, San Francisco, CA 94080 USA; [Lo, Amy A.; Giltnane, Jennifer] Genentech Inc, Dept Res Pathol, San Francisco, CA 94080 USA; [Kaufman, Susan] Genentech Inc, Dept Biochem Cellular Pharmacol, San Francisco, CA 94080 USA; [Elrod, Ashley; Lotstein, Alina; DesRochers, Teresa M.] KIYATEC Inc, Greenville, SC 29605 USA; [Munoz-Rodriguez, Jose L.] Roche Tissue Diagnost, Compan Diagnost CD, Tucson, AZ 85755 USA; [Wang, Xingwei] Roche Tissue Diagnost, Dept Digital Pathol, Santa Clara, CA 95050 USA; [Turley, Shannon J.] Genentech Inc, Dept Canc Immunol, San Francisco, CA 94080 USA
推荐引用方式 GB/T 7714	Hornburg, Milena,Desbois, Melanie,Lu, Shan,et al. Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer[J],2021,39(7):928-+.
APA	Hornburg, Milena.,Desbois, Melanie.,Lu, Shan.,Guan, Yinghui.,Lo, Amy A..,...&Wang, Yulei.(2021).Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer.CANCER CELL,39(7),928-+.
MLA	Hornburg, Milena,et al."Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer".CANCER CELL 39.7(2021):928-+.