干旱区生态环境知识资源中心(Arid): Anti-tumor activity of polysaccharides obtained from Leucocalocybe mongolica using solid-state fermentation

Arid

DOI	10.1080/13102818.2020.1807406
	Anti-tumor activity of polysaccharides obtained from Leucocalocybe mongolica using solid-state fermentation
	Zhao, Xueliang; Bau, Tolgor; Bao, Haiying
通讯作者	Bao, HY (corresponding author), Jilin Agr Univ, Minist Educ, Engn Res Ctr Edible & Med Fungi, Changchun 130118, Jilin, Peoples R China.
来源期刊	BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
ISSN	1310-2818
EISSN	1314-3530
出版年	2020
卷号	34 期号:1 页码:841-849
英文摘要	Leucocalocybe mongolica (S. Imai) is a well-known edible medicinal mushroom. Polysaccharides extracted from L. mongolica show several pharmacological properties. Owing to increased predation and desertification, wild L. mongolica populations are declining and becoming increasingly rare. Microbial fermentation is emerging as a suitable alternative to obtain bioactive compounds from this mushroom. In this study, polysaccharides were isolated from the solid-state fermentation of L. mongolica (LMPs) and their anti-tumor activities were investigated. Treatment with LMPs significantly inhibited the growth of hepatoma H22 tumors after cell transplantation in mice. Notably, LMP treatment protected the spleen and the thymus against tumor-induced damage. Furthermore, LMP administration significantly increased the serum levels of the cytokines interferon gamma, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-2, while simultaneously decreasing the serum level of vascular endothelial growth factor. Hematoxylin-eosin staining, the TUNEL assay, immunohistochemistry and western blotting indicated that the in vivo anti-tumor activity of LMP was achieved by promoting apoptosis and inhibiting angiogenesis. In summary, this study revealed that LMPs markedly suppressed the tumor growth of H22-transplanted tumors in vivo at least partly by enhancing the immune response, inducing apoptosis and inhibiting angiogenesis. These findings highlight LMP as a potential low-cost anti-tumor drug.
英文关键词	Leucocalocybe mongolica polysaccharide antitumor activity
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000686231700001
WOS关键词	TRICHOLOMA-MONGOLICUM ; ANTIOXIDANT ACTIVITIES ; CELLS ; EXTRACTION ; EXPRESSION ; APOPTOSIS ; CANCER ; OPTIMIZATION ; COMPLEX ; IL-2
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362716
作者单位	[Zhao, Xueliang; Bau, Tolgor; Bao, Haiying] Jilin Agr Univ, Minist Educ, Engn Res Ctr Edible & Med Fungi, Changchun 130118, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xueliang,Bau, Tolgor,Bao, Haiying. Anti-tumor activity of polysaccharides obtained from Leucocalocybe mongolica using solid-state fermentation[J],2020,34(1):841-849.
APA	Zhao, Xueliang,Bau, Tolgor,&Bao, Haiying.(2020).Anti-tumor activity of polysaccharides obtained from Leucocalocybe mongolica using solid-state fermentation.BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,34(1),841-849.
MLA	Zhao, Xueliang,et al."Anti-tumor activity of polysaccharides obtained from Leucocalocybe mongolica using solid-state fermentation".BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT 34.1(2020):841-849.