干旱区生态环境知识资源中心(Arid): Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis

Arid

DOI	10.1080/21655979.2021.1971036
	Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis
	Zhang, Yin; Pan, Meng; Li, Chun-Yuan; Li, Jing-ying; Ge, Wei; xu, Lai; Xiao, Yi
通讯作者	xu, L ; Xiao, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, Div Colorectal Surg, 1 Shuaifuyuan Rd, Beijing 100730, Peoples R China.
来源期刊	BIOENGINEERED
ISSN	2165-5979
EISSN	2165-5987
出版年	2021
卷号	12 期号:1 页码:6831-6843
英文摘要	This present study aimed to explore the typical protein features of tubulovillous adenoma (TVA) using proteomic and bioinformatic analyses. Tandem mass tag (TMT)-based quantitative proteomic analyses were conducted on normal mucosa, tubular adenoma, TVA and adenocarcinoma tissues. We identified 5,665 proteins categorized into seven clusters based on Pearson's correlation analysis. The bioinfomatic analysis showed mitochondrial and metabolism-related events were typical characteristics of TVA and mitochondrial-, ribosome- and matrisome-related biological processes may contribute to carcinogenesis. PLOD3 was identified as a key protein associated with the malignant potential of TVA and promoted the viability of adenoma organoids. The Cancer Genome Atlas (TCGA) analysis revealed PLOD3 as a risk factor for disease-free and overall survival. Furthermore, the PLOD3 expression correlated negatively with the abundance of B cells, CD8 + T cells, CD4 + T cells, neutrophils, macrophages and myeloid dendritic cells. In conclusion, enhanced metabolic and mitochondrial reprogramming are typical features of TVA, and PLOD3 might be related to the immune desert phenotype and contribute to TVA tumorigenesis and colorectal cancer development.
英文关键词	Tubulovillous adenoma tumorigenesis PLOD3 quantitative proteomics metabolic reprogramming tumor microenvironment
类型	Article
语种	英语
开放获取类型	gold
收录类别	SCI-E
WOS记录号	WOS:000701309300001
WOS关键词	COLORECTAL ADENOMA ; GENE-EXPRESSION ; GNAS MUTATIONS ; CANCER ; CARCINOMA ; PROGRESSION ; CYTOSCAPE ; COLON ; ADENOCARCINOMA ; DYSPLASIA
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362694
作者单位	[Zhang, Yin; xu, Lai; Xiao, Yi] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, Div Colorectal Surg, 1 Shuaifuyuan Rd, Beijing 100730, Peoples R China; [Pan, Meng; Li, Chun-Yuan; Li, Jing-ying; Ge, Wei] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci,State Key Lab Med Mol Biol, Beijing, Peoples R China; [Pan, Meng; Li, Chun-Yuan; Li, Jing-ying; Ge, Wei] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci,Dept Immunol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yin,Pan, Meng,Li, Chun-Yuan,et al. Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis[J],2021,12(1):6831-6843.
APA	Zhang, Yin.,Pan, Meng.,Li, Chun-Yuan.,Li, Jing-ying.,Ge, Wei.,...&Xiao, Yi.(2021).Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis.BIOENGINEERED,12(1),6831-6843.
MLA	Zhang, Yin,et al."Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis".BIOENGINEERED 12.1(2021):6831-6843.