干旱区生态环境知识资源中心(Arid): Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana

Arid

DOI	10.1186/s13568-021-01272-y
	Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana
	Ma, Yan; Xu, Minhua; Liu, Hancong; Yu, Tiantian; Guo, Ping; Liu, Wenbin; Jin, Xiaobao
通讯作者	Jin, XB (corresponding author), Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Peoples R China.
来源期刊	AMB EXPRESS
ISSN	2191-0855
出版年	2021
卷号	11 期号:1
英文摘要	Gordonia sp. are members of the actinomycete family, their contribution to the environment improvement and environmental protection by their biological degradation ability, but there are few studies on the antimicrobial activity of their secondary metabolites. Our team isolated and purified an actinomycete WA 4-31 from the intestinal tract of Periplaneta americana, firstly identified the strain WA 4-31 by the morphological characteristics and the phylogenetic analyses, and found it was completely homologous to the strain of Gordonia terrae from the Indian desert. Meanwhile, actinomycin D (1), actinomycin X2 (2), mojavensin A (3) and cyclic (leucine-leucne) dipeptide (4) were obtained from the EtOAc extract from the broth of WA 4-31. Compounds 1-4 showed anti-fungus activities against Candida albicans, Aspergillus niger, A. fumigatus and Trichophyton rubrum, also anti-MRSA and inhibited Escherichia coli in different degree. Interestingly, we found when 3 was mixed with 4 with ratio of 1:1, the activity of the mixture on anti-Candida albicans was better than the single. Besides, compounds 1-3 had varying degrees of antiproliferative activities on CNE-2 and HepG-2 cell lines. These indicated that Gordonia rare actinomycete from the intestinal tract of Periplaneta americana possessed a potential as a source of active secondary metabolites.
英文关键词	Gordonia Secondary metabolites Antimicrobial activity Antiproliferative activity Periplaneta americana
类型	Article
语种	英语
开放获取类型	Green Submitted, Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000679718700001
WOS关键词	NATURAL-PRODUCTS ; ANTIFUNGAL ; ENDOPHYTES
WOS类目	Biotechnology & Applied Microbiology
WOS研究方向	Biotechnology & Applied Microbiology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362434
作者单位	[Ma, Yan; Xu, Minhua; Liu, Hancong; Yu, Tiantian; Guo, Ping; Liu, Wenbin; Jin, Xiaobao] Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Peoples R China; [Ma, Yan; Xu, Minhua; Liu, Hancong; Yu, Tiantian; Guo, Ping; Liu, Wenbin; Jin, Xiaobao] Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Pharmaceut Bioact Subst, Guangzhou 510006, Peoples R China
推荐引用方式 GB/T 7714	Ma, Yan,Xu, Minhua,Liu, Hancong,et al. Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana[J],2021,11(1).
APA	Ma, Yan.,Xu, Minhua.,Liu, Hancong.,Yu, Tiantian.,Guo, Ping.,...&Jin, Xiaobao.(2021).Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana.AMB EXPRESS,11(1).
MLA	Ma, Yan,et al."Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana".AMB EXPRESS 11.1(2021).