干旱区生态环境知识资源中心(Arid): Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals

Arid

DOI	10.1002/dad2.12216
	Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals
	Collij, Lyduine E.; Mastenbroek, Sophie E.; Salvado, Gemma; Wink, Alle Meije; Visser, Pieter Jelle; Barkhof, Frederik; Berckel, Bart N. M.; Alves, Isadora Lopes
通讯作者	Collij, LE (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Radiol & Nucl Med, De Boelelaan 1117, NL-1108 HV Amsterdam, Netherlands.
来源期刊	ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
EISSN	2352-8729
出版年	2021
卷号	13 期号:1
英文摘要	Introduction The value of quantitative longitudinal and regional amyloid beta (A beta) measurements in predicting cognitive decline in initially cognitively unimpaired (CU) individuals remains to be determined. Methods We selected 133 CU individuals with two or more [C-11]Pittsburgh compound B ([C-11]PiB) scans and neuropsychological data from Open Access Series of Imaging Studies (OASIS-3). Baseline and annualized distribution volume ratios were computed for a global composite and four regional clusters. The predictive value of A beta measurements (baseline, slope, and interaction) on longitudinal cognitive performance was examined. Results Global performance could only be predicted by A beta burden in an early cluster (precuneus, lateral orbitofrontal, and insula) and the precuneus region of interest (ROI) by itself significantly improved the model. Precuneal A beta burden was also predictive of immediate and delayed episodic memory performance. In A beta subjects at baseline (N = 93), lateral orbitofrontal A beta burden predicted working and semantic memory performance. Discussion Quantifying longitudinal and regional changes in A beta can improve the prediction of cognitive functioning in initially CU individuals.
英文关键词	Alzheimer's disease amyloid beta longitudinal positron emission tomography regional
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	ESCI
WOS记录号	WOS:000680848200001
WOS关键词	ALZHEIMERS-DISEASE ; HYPOTHETICAL MODEL ; DEMENTIA ; BETA ; DEPOSITION ; NEURODEGENERATION ; IMPAIRMENT ; PREVENTION ; PATHOLOGY ; SCANS
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362433
作者单位	[Collij, Lyduine E.; Mastenbroek, Sophie E.; Wink, Alle Meije; Barkhof, Frederik; Berckel, Bart N. M.; Alves, Isadora Lopes] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands; [Salvado, Gemma] Pasqual Maragall Fdn, Barcelonasseta Brain Res Ctr BBRC, Barcelona, Spain; [Salvado, Gemma] IMIM Hosp Mar Med Res Inst, Barcelona, Spain; [Visser, Pieter Jelle] Vrije Univ Amsterdam, Alzheimer Ctr, Amsterdam UMC, Amsterdam, Netherlands; [Visser, Pieter Jelle] Vrije Univ Amsterdam, Dept Neurol, Amsterdam, Netherlands; [Barkhof, Frederik] UCL, Med Phys & Biomed Engn, Ctr Med Image Comp, London, England
推荐引用方式 GB/T 7714	Collij, Lyduine E.,Mastenbroek, Sophie E.,Salvado, Gemma,et al. Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals[J]. University of London,2021,13(1).
APA	Collij, Lyduine E..,Mastenbroek, Sophie E..,Salvado, Gemma.,Wink, Alle Meije.,Visser, Pieter Jelle.,...&Alves, Isadora Lopes.(2021).Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals.ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING,13(1).
MLA	Collij, Lyduine E.,et al."Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals".ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING 13.1(2021).