干旱区生态环境知识资源中心(Arid): T-cell Lymphoma in the Nasal Cavity in Goat

Arid

DOI	10.22456/1679-9216.113702
	T-cell Lymphoma in the Nasal Cavity in Goat
	Firmino, Millena de Oliveira; Borges, Ismael Lira; da Silveira, Gian Libanio; de Lima Tolentino, Mikael Leandro Duarte; Gomes de Queiroz, Erika de Lourdes; de Miranda Neto, Eldine Gomes; Nogueira de Galiza, Glauco Jose; Medeiros Dantas, Antonio Flavio
通讯作者	Firmino, MD (corresponding author), Hosp Vet Univ UFCG, Lab Patol Anim, Av Univ S-N, BR-58708110 Patos de Minas, PB, Brazil.
来源期刊	ACTA SCIENTIAE VETERINARIAE
ISSN	1678-0345
EISSN	1679-9216
出版年	2021
卷号	49
英文摘要	Background: Lymphomas are considered uncommon in goats, being the multicentric form with the highest number of cases for the species. Primary intranasal lymphomas are often diagnosed in dogs, cats, and humans. In the literature, there is only a description of a multicentric case involving the frontal sinuses and mucosa of the nasal cavity in a goat; therefore, it is important to describe unusual cases of this disease for the inclusion of new clinical and pathological characteristics in the ruminant clinic medicine. The objective of this work is to describe a case of T-cell lymphoma in the nasal cavity of a young goat. Case: The animal had dyspnea and respiratory noise for 15 days. Clinical examination showed nodulation in the right nasal cavity associated with serosanguinous secretion. Tracheostomy was performed; however, after 30 days the animal was euthanized. A sagittal plane of the head showed a pinkish-gray mass in the right and left nasal cavity, with a smooth, multilobulated surface, smooth adhering to the rostral portion of the dorsal concha and occluding the dorsal nasal meatus. Submandibular lymph nodes were slightly enlarged. Histopathological examination of the nasal cavity revealed a non-encapsulated, poorly delimited and ulcerated tumor composed of round cells arranged in a mantle supported by a discrete fibrovascular stroma extending the mucosa and lamina propria. Cells were round with sparse, eosinophilic and poorly delimited cytoplasm. Nuclei varied from round to elongated with condensed chromatin and evident nucleoli. Occasionally, aberrant nuclei, reniform shape and multinucleated cells were seen. Pleomorphism was moderate characterized by anisocytosis and anisocariosis. Typical and atypical mitosis were frequent (0-4 per field of highest magnification [400x]). Amidst the neoplasm, there were multifocal areas of necrosis and hemorrhage associated with a mild lymphocytic inflammatory infiltrate. Immunohistochemistry showed positive immunostaining for Vimentin antibodies and CD3, and negative for pan CK and CD20. Discussion: The lymphomas immunophenotyping is little used when it comes to farm animals, and there are few studies that use this technique for the definitive diagnosis of these neoplasms for small ruminants. The use of this technique must be considered in each case, in order to determine the pathogenesis, the accurate diagnosis and the origin of the neoplastic lymphocytes. In goats, T-cell lymphomas are the most diagnosed, although cases of multicentric B-cell lymphomas with ocular involvement have been diagnosed. In view of the clinical picture of the case described, infectious rhinitis already described in goats, such as aspergillosis and protothecosis, should be included as differential diagnoses. However, the anatomopathological findings facilitate the direction of the diagnosis, since infectious rhinitis presents as nodules / ulcerated masses or focal areas of necrosis associated with purulent secretion and in the histopathological examination it is possible to observe the intralesional etiological agents. In addition, the enzootic ethmoidal tumor must be included, as it has similar clinical signs and affects young animals, but they are adenomas/adenocarcinomas that affect the ethmoidal nasal shells induced by a retrovirus. Lymphomas in the caprine species are rare in the Northeastern semi-arid, but that in the present diagnostic routine occasionally occurs, being important the first description of its nasal shape for its inclusion in the differential diagnoses of diseases that present with clinical obstruction and dyspnea for the species.
英文关键词	hematopoietic neoplasia immunophenotyping lymphocytes dyspnea
类型	Article
语种	葡萄牙语
收录类别	SCI-E
WOS记录号	WOS:000706903900014
WOS关键词	PATHOLOGICAL ASPECTS ; CLASSIFICATION ; LYMPHOSARCOMA
WOS类目	Veterinary Sciences
WOS研究方向	Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/362314
作者单位	[Firmino, Millena de Oliveira; da Silveira, Gian Libanio; de Lima Tolentino, Mikael Leandro Duarte; de Miranda Neto, Eldine Gomes; Nogueira de Galiza, Glauco Jose; Medeiros Dantas, Antonio Flavio] Univ Fed Campina Grande UFCG, Ctr Saude & Tecnol Rural CSTR, Programa Posgrad Ciencia & Saude Anim, Campus Patos, Patos de Minas, PB, Brazil; [Borges, Ismael Lira] Pathovet Anat Patol & Patol Clin Vet, Fortaleza, Ceara, Brazil; [Gomes de Queiroz, Erika de Lourdes] MV Autonoma, Areia, PB, Brazil
推荐引用方式 GB/T 7714	Firmino, Millena de Oliveira,Borges, Ismael Lira,da Silveira, Gian Libanio,et al. T-cell Lymphoma in the Nasal Cavity in Goat[J],2021,49.
APA	Firmino, Millena de Oliveira.,Borges, Ismael Lira.,da Silveira, Gian Libanio.,de Lima Tolentino, Mikael Leandro Duarte.,Gomes de Queiroz, Erika de Lourdes.,...&Medeiros Dantas, Antonio Flavio.(2021).T-cell Lymphoma in the Nasal Cavity in Goat.ACTA SCIENTIAE VETERINARIAE,49.
MLA	Firmino, Millena de Oliveira,et al."T-cell Lymphoma in the Nasal Cavity in Goat".ACTA SCIENTIAE VETERINARIAE 49(2021).