干旱区生态环境知识资源中心(Arid): 固相萃取-超高效液相色谱-串联质谱法测定生活饮用水中11种全氟化合物

Arid

	固相萃取-超高效液相色谱-串联质谱法测定生活饮用水中11种全氟化合物
其他题名	Determination of 11 perfluorinated compounds in drinking water by solid phase extraction-ultra high performance liquid chromatography tandem mass spectrometry
	温馨; 吕佳; 陈永艳; 张岚
来源期刊	卫生研究
ISSN	1000-8020
出版年	2020
卷号	49 期号:2
中文摘要	目的建立固相萃取-超高效液相色谱串联质谱( ultra performance liquidchromatography tandem mass spectrometry,UPLC-MS /MS)同时测定生活饮用水中11种全氟化合物的方法。方法采用WAX固相萃取柱对生活饮用水样品中的目标物进行富集净化,5 mL甲醇和7 mL 0.1%氨水-甲醇溶液洗脱,洗脱液用氮气吹至近干,30%( V /V)甲醇水溶液定容至1 mL,UPLC-MS /MS进行测定。结果11种目标分析物在0.5 ~ 50 mug /L范围内具有良好的线性关系,方法检出限和定量限分别为0.03 ~0.7 ng /L和0.5 ~ 3.0 ng /L,低、中、高浓度加标回收率分别为90.0% ~ 122.3%、87.1% ~ 130.0%和80.0% ~ 113.7%,相对标准偏差分别为1.95% ~ 8.59%、1.27% ~ 9.08%和2.17% ~ 10.51%( n = 6) 。结论该方法线性范围宽,方法检出限和定量限低,适用于我国生活饮用水中11种全氟化合物的测定和监测。
英文摘要	OBJECTIVE To develop a method for the determination of 11 perfluorinated compounds ( PFCs ) in drinking water by solid phase extraction-ultra performance liquid chromatography tandem mass spectrometry ( UPLC-MS /MS ). METHODS The target analytes in water samples were concentrated and purified by Oasis WAX SPE column and eluted with 5 mL methanol and 7 mL 0.1% ammonia-methanol solution. The eluent was blown to near dryness under a nitrogen gas, diluting with methanol water solution( 3∶ 7,V/V) to 1 mL for analysis by UPLC-MS /MS. RESULTS There were good liner relationship in the range of 0.5 - 50 mug /L. The detection limit and the limit of quantitation were 0.03 - 0.7 ng /L and 0.5 - 3.0 ng /L, respectively. The recoveries of 11 PFCs at three different spiked concentrations were 90.0% - 122.3%,87.1% - 130.0% and 80.0% - 113.7%,respectively,and the relative standard deviation were 1.95% - 8.59%,1.27% -9.08% and 2.17% -10.51%( n =6), respectively. CONCLUSION This method has wide linear range,low detection limit and limit of quantitation,applicable for simultaneous analysis and monitorting of 11 PFCs in drinking water.
中文关键词	全氟化合物 ; 固相萃取 ; 超高效液相色谱-串联质谱 ; 饮用水
英文关键词	perfluorinated compounds solid phase extraction ultra performance liquid chromatography tandem mass spectrometry drinking water
类型	Article
语种	中文
收录类别	CSCD
WOS类目	Public, Environmental & Occupational Health
CSCD记录号	CSCD:6706485
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/353906
作者单位	温馨, 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050, 中国. 吕佳, 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050, 中国. 陈永艳, 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050, 中国. 张岚, 中国疾病预防控制中心环境与健康相关产品安全所, 北京 100050, 中国.
推荐引用方式 GB/T 7714	温馨,吕佳,陈永艳,等. 固相萃取-超高效液相色谱-串联质谱法测定生活饮用水中11种全氟化合物[J],2020,49(2).
APA	温馨,吕佳,陈永艳,&张岚.(2020).固相萃取-超高效液相色谱-串联质谱法测定生活饮用水中11种全氟化合物.卫生研究,49(2).
MLA	温馨,et al."固相萃取-超高效液相色谱-串联质谱法测定生活饮用水中11种全氟化合物".卫生研究 49.2(2020).