干旱区生态环境知识资源中心(Arid): Molecular Docking Evaluation of the Desert Truffles as Potent Antifungal Inhibitors

Arid

DOI	10.9734/JPRI/2021/v33i531179
	Molecular Docking Evaluation of the Desert Truffles as Potent Antifungal Inhibitors
	Al-Mazaideh, Ghassab M.; Al-Swailmi, Farhan K.; Parrey, Mujeeb Ur Rehman
通讯作者	Al-Mazaideh, GM (corresponding author), Univ Hafr Al Batin, Coll Pharm, Dept Pharmaceut Chem, Hafar al Batin, Saudi Arabia.
来源期刊	JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
ISSN	2456-9119
出版年	2021
卷号	33 期号:5 页码:36-48
英文摘要	The research investigated the possible antifungal behavior of forty-four truffles bioactive compounds conducted to investigate the interaction modes of these inhibitors against three different types of the fungal proteins: Candida albicans, Blastomyces dermatitidis, and Ganoderma microsporum. The applied method in contrast to ketoconazole and griseofulvin revealed the possible anti-fungal agents ergosterol, Catechin gallate and rutin. With respect to Candida Albicans, the maximum possible binding energy was ergosterol (-11.75 Kcal/mol), followed then by catechin gallate (-11.46 Kcal/mol) then rutin (-9.90 Kcal/mol). Compared to Blastomyces, Ganoderma microsporum fungal protein with most negative binding energy among other components of the truffle is found to be of a relatively similar behavior for the same compounds. Ergosterol demonstrated the highest binding capacity for dermatitidis, while rutin scored the lowest against Ganoderma microsporum. The possible anti-fungal components of desert truffle have yet to be studied in vitro in the future.
英文关键词	Molecular docking Deseret truffles Candida albicans Blastomyces dermatitidis ganoderma microsporum
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	ESCI
WOS记录号	WOS:000627853500005
WOS关键词	SITE
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/352898
作者单位	[Al-Mazaideh, Ghassab M.] Univ Hafr Al Batin, Coll Pharm, Dept Pharmaceut Chem, Hafar al Batin, Saudi Arabia; [Al-Swailmi, Farhan K.] Univ Hafr Al Batin, Coll Pharm, Dept Pharm Practice, Hafar al Batin, Saudi Arabia; [Parrey, Mujeeb Ur Rehman] Northern Border Univ, Fac Med, Dept Surg, Ar Ar, Saudi Arabia
推荐引用方式 GB/T 7714	Al-Mazaideh, Ghassab M.,Al-Swailmi, Farhan K.,Parrey, Mujeeb Ur Rehman. Molecular Docking Evaluation of the Desert Truffles as Potent Antifungal Inhibitors[J],2021,33(5):36-48.
APA	Al-Mazaideh, Ghassab M.,Al-Swailmi, Farhan K.,&Parrey, Mujeeb Ur Rehman.(2021).Molecular Docking Evaluation of the Desert Truffles as Potent Antifungal Inhibitors.JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL,33(5),36-48.
MLA	Al-Mazaideh, Ghassab M.,et al."Molecular Docking Evaluation of the Desert Truffles as Potent Antifungal Inhibitors".JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL 33.5(2021):36-48.